A review of feline infectious peritonitis virus: molecular biology, immunopathogenesis, clinical aspects, and vaccination

• Published in: Veterinary microbiology Vol. 36; no. 1; pp. 1 - 37
• Main Author: Olsen, Christopher W.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.07.1993; Elsevier Science; Published by Elsevier B.V
• Subjects: Animal viral diseases; Animals; BIOLOGIA MOLECULAR; Biological and medical sciences; BIOLOGIE MOLECULAIRE; Cat Diseases - diagnosis; Cat Diseases - immunology; Cat Diseases - prevention & control; CATS; CHAT; Coronavirus, Feline - genetics; Coronavirus, Feline - immunology; ENFERMEDADES INMUNOLOGICAS; FELINE INFECTIOUS PERITONITIS; Feline Infectious Peritonitis - diagnosis; Feline Infectious Peritonitis - immunology; Feline Infectious Peritonitis - prevention & control; feline infectious peritonitis virus; GATO; IMMUNOLOGICAL DISEASES; Infectious diseases; MALADIE IMMUNOLOGIQUE; Medical sciences; MOLECULAR BIOLOGY; PERITONITE INFECTIEUSE FELINE; PERITONITIS INFECCIOSA FELINA; VACCINATION; Vaccination - veterinary; VACUNACION; Viral diseases; Viral Proteins - immunology; Viral Vaccines; VIROSE; VIROSES; VIROSIS; Fissipedia; Carnivora; Recombination; Immune response; Feline infectious peritonitis virus; Vaccine; Review; Host virus relation; Virus; Pathogenicity; Vertebrata; Coronavirus; Mammalia; Animal; Infectivity; Cat; Coronaviridae; Molecular biology
• ISSN: 0378-1135; 1873-2542
• DOI: 10.1016/0378-1135(93)90126-R

Feline infectious peritontis (FIP) has been an elusive and frustrating problem for veterinary practitioners and cat breeders for many years. Over the last several years, reports have begun to elucidate aspects of the molecular biology of the causal virus (FIPV). These papers complement a rapidly growing base of knowledge concerning the molecular organization and replication of coronaviruses in general. The fascinating immunopathogenesis of FIPV infection and the virus' interaction with macrophages has also been the subject of several recent papers. It is now clear that FIPV may be of interest to scientists other than veterinary virologists since its pathogenesis may provide a useful model system for other viruses whose infectivity is enhanced in the presence of virus-specific antibody. With these advances and the recent release of the first commercially-available FIPV vaccine, it is appropriate to review what is known about the organization and replication of coronaviruses and the pathogenesis of FIPV infection.