Long-Term Consequences of Kidney Donation

• Published in: The New England journal of medicine Vol. 360; no. 5; pp. 459 - 469
• Main Authors: Ibrahim, Hassan N, Foley, Robert, Tan, LiPing, Rogers, Tyson, Bailey, Robert F, Guo, Hongfei, Gross, Cynthia R, Matas, Arthur J
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 29.01.2009
• Subjects: Adult; Age Factors; Albuminuria - epidemiology; Biological and medical sciences; Case-Control Studies; Creatinine - blood; Donations; Ethnic Groups; Female; Follow-Up Studies; General aspects; Glomerular Filtration Rate; Health Status; Humans; Hypertension - epidemiology; Kidney diseases; Kidney Failure, Chronic - epidemiology; Kidney Failure, Chronic - etiology; Kidney Transplantation - adverse effects; Kidney Transplantation - mortality; Living Donors; Male; Medical sciences; Middle Aged; Multivariate Analysis; Quality of Life; Risk; Studies; Survivors; Transplants & implants; United States > US; Medicine; Long term; Kidney
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa0804883

This study examined the vital status and lifetime risk of end-stage renal disease in 3698 persons who donated a kidney between 1963 and 2007. The results indicate that survival and the risk of end-stage renal disease among carefully screened kidney donors appear to be similar to those in the general population. Most donors who were studied had a preserved glomerular filtration rate, normal albumin excretion, and an excellent quality of life. Survival and the risk of end-stage renal disease among carefully screened kidney donors appear to be similar to those in the general population. Most donors who were studied had a preserved glomerular filtration rate, normal albumin excretion, and an excellent quality of life. Kidney transplantation, particularly from a living donor, is the treatment of choice for most patients with end-stage renal disease (ESRD). 1 The superior results achieved with kidney transplantation from living donors have resulted in an increase in this method of transplantation. 2 The life expectancy of kidney donors appears to be similar to that of nondonors or perhaps even longer, as suggested by one study. 3 However, at least two reports have described donors in the United States who were subsequently placed on the waiting list for kidney transplantation. 4 , 5 Although the risk of ESRD among donors does not appear to be increased, . . .