HBV细胞模型研究进展

HBV感染已成为肝癌发病的最主要原因,建立一系列HBV细胞模型为研究HBV的致病机理和治疗奠定了良好的基础。介绍了以HBV转染和感染为主的单一种类细胞培养模型、多种细胞共培养模型以及其他动物模型,探讨HBV感染细胞模型的建立方法及其病毒学特点,为科学阐释中医药防治慢性乙型肝炎的优势作用环节提供可靠的模型依据。...

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Published in临床肝胆病杂志 Vol. 31; no. 7; pp. 1168 - 1172
Main Author 吴疆 周振华 孙学华 朱晓骏 李曼 张鑫 高月求
Format Journal Article
LanguageChinese
Published 上海中医药大学附属曙光医院肝病科,上海市中医临床重点实验室,上海201203 2015
Subjects
细胞培养技术
综述
肝炎病毒,乙型
细胞培养技术
综述
肝炎病毒,乙型
hepatitis B virus
cell culture techniques
review
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2015.07.043

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Summary:HBV感染已成为肝癌发病的最主要原因,建立一系列HBV细胞模型为研究HBV的致病机理和治疗奠定了良好的基础。介绍了以HBV转染和感染为主的单一种类细胞培养模型、多种细胞共培养模型以及其他动物模型,探讨HBV感染细胞模型的建立方法及其病毒学特点,为科学阐释中医药防治慢性乙型肝炎的优势作用环节提供可靠的模型依据。
Bibliography:Hepatitis B virus（ HBV） infection has become the main cause of hepatocellular carcinoma. A series of cell models for HBV infection are established to lay a good foundation for the research on the pathogenesis and treatment of HBV. In this review,we summarize culture models for a single type of cells,co- culture models for multiple types of cells,and other animal models,which are mainly for HBV transfection and infection. We also discuss the methods of cell model construction for HBV infection and their virological characteristics. It provides reliable evidence of models for scientific interpretation of advantages of traditional Chinese medicine in the prevention and treatment of chronic hepatitis B.
WU Jiang, ZHOU Zhenhua, SUN Xuehua, et al. （ Department of Hepatopathy, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China）
hepatitis B virus; cell culture techniques; review
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.07.043