先天性胆道闭锁的病因研究进展

先天性胆道闭锁是一种发病机制尚未完全清楚的多病因、多表型的新生儿罕见疾病,当前对其病因学研究的热点主要集中于病毒感染、免疫失调以及发育异常等方面。归纳了目前先天性胆道闭锁主流的病因假说及各假说之间的联系,认为这些研究进展为病因探索和新的防治手段提供了宝贵的线索和依据。...

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Published in临床肝胆病杂志 Vol. 31; no. 8; pp. 1343 - 1346
Main Author 郭振亚 张若岩 柳明江 杜晓宏 张平 王广义 叶军锋
Format Journal Article
LanguageChinese
Published 吉林大学白求恩第一医院肝胆胰外科,长春,130021 2015
Subjects
婴儿,新生
病因
综述
胆道闭锁
biliary atresia
婴儿,新生
infant,newbern
病因
review
胆道闭锁
综述
etiology
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2015.08.043

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Summary:先天性胆道闭锁是一种发病机制尚未完全清楚的多病因、多表型的新生儿罕见疾病,当前对其病因学研究的热点主要集中于病毒感染、免疫失调以及发育异常等方面。归纳了目前先天性胆道闭锁主流的病因假说及各假说之间的联系,认为这些研究进展为病因探索和新的防治手段提供了宝贵的线索和依据。
Bibliography:GUO Zhenya, ZHANG Ruoyan, LIU Mingfiang, et al. （ Department of Hepato - Biliary - Pancreatic Surgery, The First Hospital of Jilin University, Changchun 130021, China）
biliary atresia; etiology; infant; newbern; review
Congenital biliary atresia is considered a neonatal rare disease with multiple causes and phenotypes,whose pathogenesis remains unclear. At present,the etiological study of congenital biliary atresia mainly focuses on viral infection,immune disorder,and dysplasia.This paper summarizes the main etiological hypotheses about congenital biliary atresia nowadays and the connections between them. The research progress provides valuable clues and evidence for the etiology and control of this disease.
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.08.043