HCV感染动物模型的研究进展

理想的HCV感染动物模型的建立,不仅有利于研究慢性丙型肝炎的致病机制（包括病毒-宿主相互作用、病毒变异性、宿主免疫应答规律）,还为抗病毒药物的筛选和预防性疫苗的研发提供了更有效的技术途径。介绍了目前大家熟知的动物模型,包括黑猩猩模型、树鼩模型、小鼠模型等,并对各种模型的优势与缺陷进行了分析。近年来HCV感染小动物模型,尤其是转基因小鼠模型的建立,为HCV感染动物模型开创了新领域,是动物模型研究的热点和重点。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 31; no. 1; pp. 123 - 126
Main Author 朱婷 聂青和
Format Journal Article
LanguageChinese
Published 第四军医大学唐都医院 传染病科,西安,710038 2015
Subjects
感染
模型,动物
综述
肝炎病毒属
模型,动物
infection
hepacivirus
肝炎病毒属
review
感染
综述
model,animal
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Summary:理想的HCV感染动物模型的建立,不仅有利于研究慢性丙型肝炎的致病机制（包括病毒-宿主相互作用、病毒变异性、宿主免疫应答规律）,还为抗病毒药物的筛选和预防性疫苗的研发提供了更有效的技术途径。介绍了目前大家熟知的动物模型,包括黑猩猩模型、树鼩模型、小鼠模型等,并对各种模型的优势与缺陷进行了分析。近年来HCV感染小动物模型,尤其是转基因小鼠模型的建立,为HCV感染动物模型开创了新领域,是动物模型研究的热点和重点。
Bibliography:An animal model of hepatitis C virus （HCV）infection involves the use of an animal to build the model for simulating the whole process of HCV infection in humans.Establishing an ideal animal model for HCV infection is conducive to study on the pathogenesis of chro-nic hepatitis C,including virus-host interactions,viral variability,and host immune response patterns.Additionally,it provides a more ef-fective technical strategy for screening antiviral drugs and developing preventive vaccines.This article summarizes well-known animal mod-els of HCV infection,such as those established in chimpanzees,tree shrews,and mice.The advantages and drawbacks of each kind of ani-mal models are analyzed.In recent years,the establishment of small animal models,particularly those in transgenic mice,has opened up a new field in the development of animal models of HCV infection,which will be the hotspot and emphasis of relevant animal model studies.
hepacivirus;model,animal;infection;review
ZHU Ting, NIE Qinghe. （Department of Infec
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2015.01.028