Tracking mechanical wave propagation within tissue using phase-sensitive optical coherence tomography: motion artifact and its compensation

• Published in: Journal of biomedical optics Vol. 18; no. 12; p. 121505
• Main Authors: Song, Shaozhen, Huang, Zhihong, Wang, Ruikang K
• Format: Journal Article
• Language: English
• Published: United States Society of Photo-Optical Instrumentation Engineers 01.12.2013
• Subjects: Biomechanical Phenomena - physiology; Compensation; Humans; Models, Biological; Movement - physiology; Optical Coherence Tomography; Phantoms, Imaging; Refractive index; Signal Processing, Computer-Assisted; Sound waves; Surface motion; Tomography, Optical Coherence - instrumentation; Tomography, Optical Coherence - methods; Tracking; Wave propagation; mechanical wave imaging; phase-sensitive optical coherence tomography; motion artifact; motion detection
• ISSN: 1083-3668; 1560-2281; 1560-2281
• DOI: 10.1117/1.JBO.18.12.121505

We describe theoretical and experimental investigations of motion artifacts that can arise in the detection of shear wave propagating within tissue with phase-sensitive optical coherence tomography. We find that the motion artifact is a combined product of sample surface motion and refractive index difference between sample and air, which cannot be neglected when estimating the tissue motion within tissue. A method of compensating the motion artifact is demonstrated, the results of which emphasize the need for surface motion compensation when measuring the mechanical response for elastography or other biomedical applications.