Amino alcohol-based degradable poly(ester amide) elastomers

• Published in: Biomaterials Vol. 29; no. 15; pp. 2315 - 2325
• Main Authors: Bettinger, Christopher J, Bruggeman, Joost P, Borenstein, Jeffrey T, Langer, Robert S
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.05.2008
• Subjects: Advanced Basic Science; Amino Alcohols - chemistry; Animals; Biocompatible Materials - chemical synthesis; Biocompatible Materials - chemistry; Biocompatible Materials - metabolism; Biodegradable; Biomechanical Phenomena; Cells, Cultured; Decanoic Acids - chemistry; Dentistry; Dicarboxylic Acids - chemistry; Elastomer; Elastomers - chemical synthesis; Elastomers - chemistry; Elastomers - metabolism; Electron Probe Microanalysis; Female; Fibroblasts - cytology; Fibroblasts - metabolism; Glycerol - chemistry; Humans; Materials Testing - methods; Molecular Structure; Molecular Weight; Polyesters - chemical synthesis; Polyesters - chemistry; Polyesters - metabolism; Propanolamines - chemistry; Rats; Rats, Sprague-Dawley; Sugar Alcohols - chemistry; Tensile Strength; Tissue engineering; Tissue Scaffolds - chemistry; Transition Temperature; Tissue engineering; Biodegradable; Elastomer
• ISSN: 0142-9612; 1878-5905
• DOI: 10.1016/j.biomaterials.2008.01.029

Abstract Currently available synthetic biodegradable elastomers are primarily composed of crosslinked aliphatic polyesters, which suffer from deficiencies including (1) high crosslink densities, which results in exceedingly high stiffness, (2) rapid degradation upon implantation, or (3) limited chemical moieties for chemical modification. Herein, we have developed poly(1,3-diamino-2-hydroxypropane- co -polyol sebacate)s, a new class of synthetic, biodegradable elastomeric poly(ester amide)s composed of crosslinked networks based on an amino alcohol. These crosslinked networks feature tensile Young's modulus on the order of 1 MPa and reversable elongations up to 92%. These polymers exhibit in vitro and in vivo biocompatibility. These polymers have projected degradation half-lives up to 20 months in vivo.