Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene

• Published in: Molecular brain Vol. 11; no. 1; p. 53
• Main Authors: Jiménez, Karen M, Pereira-Morales, Angela J, Adan, Ana, Lopez-Leon, Sandra, Forero, Diego A
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 21.09.2018; BioMed Central; BMC
• Subjects: Adults; Anxiety; Behavior disorders; Binding Sites - genetics; Candidates; Deoxyribonucleic acid; Depression (Mood disorder); Depression - genetics; Depressive symptoms; Depressió psíquica; DNA; Dopaminergic genes; Female; Fibroblast growth factor 20; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblasts; Gene polymorphism; Genes; Genetic aspects; Genetic polymorphisms; Gens; Growth factors; Hospitals; Humans; Male; Mental depression; Mental disorders; Mental health; Micro RNAs; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; Neurogenesis; Non-coding RNA; Parkinson's disease; Polymorphism, Single Nucleotide - genetics; Psychiatry; Psychological aspects; Risk factors; Salut mental; Statistical analysis; Studies; Young Adult; Young adults; Colombia; United States > US; Spain; Depressive symptoms; Dopaminergic genes; MicroRNAs; Mental health
• ISSN: 1756-6606; 1756-6606
• DOI: 10.1186/s13041-018-0397-0

Genetic studies of major depressive disorder and its associated endophenotypes are useful for the identification of candidate genes. In recent years, variations in non-coding RNA genes, such as miRNAs, have been explored as novel candidates for psychiatric disorders and related endophenotypes. The aim of the present study was to evaluate the possible association between a functional polymorphism (rs12720208) in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms in young adults. A sample of 270 participants from Colombia were evaluated with the Hospital Anxiety and Depression Scale - Depression Subscale (HADS-D) and genotyped for the rs12720208 polymorphism using a TaqMan assay. A lineal regression analysis was used. A statistically significant association of the functional polymorphism in the FGF20 gene (rs12720208) with depressive symptoms was found. It was observed that individuals with the G/A genotype had higher scores for the HADS-D subscale. Our results are the first description in the scientific literature about a significant association between a functional polymorphism in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms.