Membrane transporter engineering in industrial biotechnology and whole cell biocatalysis

Highlights • Transporters are a relatively undervalued set of proteins contributing to the control of biotechnological fluxes. • We highlight the evidence for this. • This is true for both ‘influx’ and ‘efflux’ transporters. • Transporter engineering offers many opportunities to overcome flux contro...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 33; no. 4; pp. 237 - 246
Main Authors Kell, Douglas B, Swainston, Neil, Pir, Pınar, Oliver, Stephen G
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.04.2015
Elsevier Limited
Subjects
Bacteria
Biotechnology
Drug resistance
drug transporters
E coli
Fermentation
flux improvements
Gene Expression Profiling
GWAS
Internal Medicine
Membrane Transport Proteins
Membranes
Metabolic Engineering
Metabolism
Metabolites
Mutation
Pharmaceutical industry
Protein Engineering
stress tolerance
Synthetic Biology
drug transporters
biotechnology
stress tolerance
GWAS
flux improvements
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Summary:Highlights • Transporters are a relatively undervalued set of proteins contributing to the control of biotechnological fluxes. • We highlight the evidence for this. • This is true for both ‘influx’ and ‘efflux’ transporters. • Transporter engineering offers many opportunities to overcome flux control. • The methods of synthetic biology offer particular promise for transporter engineering.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2015.02.001