STUDIES ON THE EFFECTS OF 3-ACETYL-4″-ISOVALERYLTYLOSIN AGAINST MULTIPLE-DRUG RESISTANT STRAINS OF STAPHYLOCOCCUS AUREUS

• Published in: Journal of antibiotics Vol. 34; no. 3; pp. 305 - 312
• Main Authors: TSUCHIYA, MASAMI, SUZUKAKE, KAYOKO, HORI, MAKOTO, SAWA, TSUTOMU, TAKEUCHI, TOMIO, UMEZAWA, HAMAO, OKAMOTO, ROKURO, NOMURA, HIDEO, TSUNEKAWA, HIROSHI, INUI, TAIJI
• Format: Journal Article
• Language: English
• Published: Japan JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 01.01.1981
• Subjects: Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Bacterial Proteins - biosynthesis; Drug Resistance, Microbial; Leucomycins - pharmacology; Staphylococcus aureus - drug effects; Structure-Activity Relationship; Tylosin - analogs & derivatives
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.34.305

The macrolide-resistance of multiple-drug resistant strains of Staphylococcus aureus was divided into two types; the decreased sensitivity of ribosomes (type I) and the decreased uptake (type II). Both types were resistant to erythromycin, tylosin and 3-acetyltylosin, and their resistance was not inducible. 3-Acetyl-4″-isovaleryltylosin inhibited the growth of both types. Protein synthesis on ribosomes of type I in vitro (S. aureus MS-9610) was inhibited by 3-acetyl-4″-isovaleryltylosin, but little or no inhibition was seen with either tylosin or 3-acetyltylosin. Ribosomes of type II in vitro (S. aureus MS-8710) were sensitive to all macrolides. 3-Acetyl-4"-isovaleryltylosin accumulated about twice as much as 3-acetyltylosin in intact cells of type II.