The Inhibitory Effect of Sulfated Schizophyllans and Related Oligosaccharides on Coagulation and Fibrinolysis

• Published in: Biological & pharmaceutical bulletin Vol. 17; no. 5; pp. 739 - 741
• Main Authors: HIRATA, Akio, NAGAMATSU, Yoko, ITOH, Wataru, TABATA, Kengo, YAMAMOTO, Junichiro, OKADA, Yoshio
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1994; Maruzen; Japan Science and Technology Agency
• Subjects: Amino Acid Sequence; Animals; Biological and medical sciences; Blood Coagulation - drug effects; Carbohydrate Sequence; Cattle; coagulation; Endopeptidases - metabolism; Fibrinolysin - antagonists & inhibitors; Fibrinolysin - metabolism; fibrinolysis; Fibrinolysis - drug effects; General pharmacology; Humans; inhibitory activity; Medical sciences; Molecular Sequence Data; Molecular Weight; Oligosaccharides - pharmacology; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; plasmin; Prothrombin Time; Sizofiran - pharmacology; sulfated oligosaccharide; sulfated schizophyllan; Thrombin Time; Blood coagulation; Serine endopeptidases; Enzyme; Pharmacognosy; Oligosaccharide; Basidiomycetes; Extract; Fibrinolysis; Biological activity; Plasmin; Thrombin time; Medicinal plant; Sulfatation; Fungi; Schizophyllum commune; Prothrombin time; Plant origin; Hydrolases; Sulfur; Proteinases; Thallophyta
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.17.739

Sulfated schizophyllans and sulfated oligosaccharides were prepared and their inhibitory effects on coagulation and fibrinolysis were examined. Some sulfated schizophyllans, which had a sulfur content of more than 10%, prolonged prothrombin time (PT) and thrombin time (TT). Interestingly, some sulfated schizophyllans and related oligosaccharides were able to inhibit plasmin toward fibrinolysis and amidolysis.