m-Coumaric acid attenuates non-catalytic protein glycosylation in the retinas of diabetic rats

• Published in: Journal of Pesticide Science Vol. 43; no. 3; pp. 180 - 185
• Main Authors: Moselhy, Said Salama, Razvi, Syed Shoeb, ALshibili, Fawzia A., Kuerban, Abudukadeer, Hasan, Mohammed Nihal, Balamash, Khadijah Saeed, Huwait, Etimad A., Abdulaal, Wesam H., Al-Ghamdi, Maryam A., Kumosani, Taha A., Abulnaja, Khalid Omar, Al-Malki, Abdulrahman L., Asami, Tadao, Ismail, Iman M.
• Format: Journal Article
• Language: English
• Published: Japan Pesticide Science Society of Japan 20.08.2018; Japan Science and Technology Agency
• Subjects: Acids; Advanced glycosylation end products; AGEs; Antioxidants; Body weight; Catalysis; Coumaric acid; Diabetes; Diabetes mellitus; diabetic rats; Diabetic retinopathy; Glucose; Glycosylation; HCA; Hemoglobin; Hyperglycemia; Insulin; m-coumaric acid; Original; Proteins; Retina; Retinopathy; Rodents; Subgroups; diabetic rats; hyperglycemia; AGEs; retinopathy; m-coumaric acid; HCA
• ISSN: 1348-589X; 1349-0923
• DOI: 10.1584/jpestics.D17-091

In this study, we investigated the inhibitory effects of m-coumaric acid on the glycosylation of proteins in the retinas of diabetic rats. Male rats were divided into two main groups, Group I (normal control) and Group II (diabetic); Group II was further divided into four subgroups: Group IIa (diabetic control), Group IIb (diabetic rats were given m-coumaric acid orally [150 mg/kg, body weight (bw)/day]), Group IIc (diabetic rats were given HCA m-coumaric acid orally [300 mg/kg bw/day]), and Group IId (diabetic rats were given insulin [10 units/kg bw/day]) as a positive control). The treatment lasted for six weeks, and the data obtained suggested that m-coumaric acid reduced glucose and glycated hemoglobin levels, which further decreased the formation of glucose-derived advanced glycation end products. Hence, it protected the tissues from the detrimental effects of hyperglycemia and enhanced antioxidant activity. In conclusion, m-coumaric acid could be a potential candidate to prevent the onset and progression of retinopathy in diabetic patients.