Abdominal manifestations of IgG4-related disease: a pictorial review

• Published in: Insights into imaging Vol. 9; no. 4; pp. 437 - 448
• Main Authors: Tang, Christopher Siew Wai, Sivarasan, Nishanth, Griffin, Nyree
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.08.2018; Springer Nature B.V; SpringerOpen
• Subjects: Abdomen; Autoimmune diseases/diagnosis; Autoimmune pancreatitis; Diagnostic Radiology; IgG4; Imaging; Immunoglobulin G; Internal Medicine; Interventional Radiology; Medical diagnosis; Medicine; Medicine & Public Health; Neuroradiology; Pancreatitis; Pictorial Review; Radiology; Ultrasound; IgG4; Autoimmune pancreatitis; Immunoglobulin G; Autoimmune diseases/diagnosis
• ISSN: 1869-4101; 1869-4101
• DOI: 10.1007/s13244-018-0618-1

In the last decade, autoimmune pancreatitis has become recognised as part of a wider spectrum of IgG4-related disease, typically associated with elevated serum IgG4 levels and demonstrating a response to corticosteroid therapy. Radiologically, there is imaging overlap with other benign and neoplastic conditions. This pictorial review discusses the intra-abdominal manifestations of this disease on cross-sectional imaging before and after steroid treatment and the main radiological features which help to distinguish it from other key differentials. Teaching Points • Autoimmune pancreatitis is part of a spectrum of IgG4-related disease. • Diagnosis is based on raised serum IgG4, clinical, radiological and histopathological findings. • Cross-sectional imaging can demonstrate the typical findings of abdominal IgG4-related disease. • Cross-sectional imaging can be used to monitor response to corticosteroid treatment.