Cytotoxic Activities of Solanum Steroidal Glycosides

• Published in: Biological & pharmaceutical bulletin Vol. 19; no. 4; pp. 564 - 566
• Main Authors: NAKAMURA, Takanori, KOMORI, Chieko, LEE, Yun-yun, HASHIMOTO, Fumio, YAHARA, Shoji, NOHARA, Toshihiro, EJIMA, Akio
• Format: Journal Article
• Language: English
• Published: Tokyo The Pharmaceutical Society of Japan 1996; Maruzen; Japan Science and Technology Agency
• Subjects: Antineoplastic Agents - pharmacology; Biological and medical sciences; cytotoxic activity; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal - pharmacology; General pharmacology; Glycosides - chemistry; Glycosides - pharmacology; Humans; Medical sciences; Molecular Structure; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - chemistry; Plant Extracts - pharmacology; Solanum alkaloid; Solanum tuberosum; steroidal glycoside; Steroids - chemistry; Steroids - pharmacology; Tumor Cells, Cultured; β-chacotriosyl moiety; Steroid; Cell culture; Cytotoxicity; In vitro; Alkaloid; Structure activity relation; Dicotyledones; Angiospermae; Plant origin; Spermatophyta; Glycoside; Solanaceae; Solanum
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.19.564

Cytotoxic activities of 20 steroidal glucosides obtained from Solanum genera plants were examined against various cell lines to provide new evidence as follows : 1) As regarding the sugar linkage, the glucosides possessing a β-chacotriosyl moiety were the most effective and the presence of the terminal rhamnosyl residue was required for exhibiting strong activity. 2) As for the aglycone, the glycosides carrying a spirostanol aglycone showed the strongest activity and even an aglycone without a sugar linkage presented considerably strong activity.