Depigmenting effect of catechins

The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA). The catechin group inhibited melanin synthesis in B16 melanoma cells. To...

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Bibliographic Details
Published inMolecules (Basel, Switzerland) Vol. 14; no. 11; pp. 4425 - 4432
Main Authors Sato, Kazuomi, Toriyama, Masaru
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 04.11.2009
Molecular Diversity Preservation International
Subjects
Acids
Animals
B16 melanoma
catechin
Catechin - analogs & derivatives
Catechin - chemistry
Catechin - pharmacology
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Communication
gallic acid
Gallic Acid - chemistry
Gallic Acid - pharmacology
Gene Expression - drug effects
Investigations
Melanins - metabolism
melanogenesis
Melanoma
Mice
Molecular Structure
Monophenol Monooxygenase - metabolism
Oxidation
Proteins
tyrosinase
α-MSH (α-melanocyte stimulating hormone)
Japan
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Summary:The aim of the present work was to clarify the anti-melanogenic mechanism of the catechin group. In this study, we used (-)-epigallocatechin-3-gallate (EGCG), (-)-epigallocatechin (EGC), (-)-catechin (C), and gallic acid (GA). The catechin group inhibited melanin synthesis in B16 melanoma cells. To elucidate the anti-melanogenic mechanism of the catechin group, we performed Western blotting analysis for crucial melanogenic protein, namely tyrosinase. The catechin group inhibited tyrosinase expression. These results indicate that the catechin group is a candidate anti-melanogenic agent and that it might be effective in hyperpigmentation disorders.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules14114425