T细胞免疫球蛋白黏蛋白分子3与HBV感染的研究进展

研究发现T细胞免疫球蛋白黏蛋白分子（TIM）3与许多疾病的发病相关联。HBV感染机体时,TIM-3作为一个负性免疫调节分子,在CD8＋T细胞上的表达明显增高,这表明它与HBV的发病机制密切相关。从TIM-3的生物学特性、HBV疾病转归和治疗靶点等方面回顾总结了TIM-3与HBV感染的最新研究进展,认为TIM-3将会成为HBV治疗的新靶点。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 30; no. 9; pp. 935 - 938
Main Author 董杰 申焕君 杨晓菲 赵荣荣 张野 赵燕燕 黄长形 连建奇
Format Journal Article
LanguageChinese
Published 第四军医大学唐都医院 传染科,西安,710038 2014
Subjects
T细胞免疫球蛋白黏蛋白分子3
综述
肝炎病毒,乙型
T细胞免疫球蛋白黏蛋白分子3
T cell immunoglobulin and mucin domin containing molecule-3
综述
肝炎病毒,乙型
hepatitis B virus
review
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.09.025

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Summary:研究发现T细胞免疫球蛋白黏蛋白分子（TIM）3与许多疾病的发病相关联。HBV感染机体时,TIM-3作为一个负性免疫调节分子,在CD8＋T细胞上的表达明显增高,这表明它与HBV的发病机制密切相关。从TIM-3的生物学特性、HBV疾病转归和治疗靶点等方面回顾总结了TIM-3与HBV感染的最新研究进展,认为TIM-3将会成为HBV治疗的新靶点。
Bibliography:DONG Jie, SHEN Huanjun, YANG Xiaofei, et al. （ Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi＇an 710038, China）
hepatitis B virus; T cell immunoglobulin and mucin domin containing molecule-3; review
Studies have found that T cell Ig- and mucin- domain- containing molecule- 3（ TIM- 3） is associated with the development of many diseases. In hepatitis B virus（ HBV） infection,TIM- 3 acts as a negative immune regulatory molecule and its expression on CD8＋T cells increases markedly. It indicates that TIM- 3 is closely related to the pathogenic mechanism of HBV infection. The latest research progress in TIM- 3 and HBV infection,including the biological characteristics of TIM- 3 and the outcomes and new therapeutic target of HBV infection,is reviewed and summarized. It is thought that TIM- 3 will become a new target in the treatment of HBV.
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.09.025