白桦酸体外对人肝癌细胞、鼻咽癌细胞增殖及组织血管生成的影响

目的观察白桦酸（BA）对肿瘤细胞增殖及组织血管生成的影响。方法培养人肝癌细胞株Bel-7402、人鼻咽癌细胞株CNE、人血管内皮细胞株HMEC,分别以不同浓度的BA干预,比较Bel-7402细胞和CNE细胞增殖抑制率、凋亡率,并比较HMEC细胞增殖抑制率、迁移能力、血管形成能力。结果 BA可抑制Bel-7402细胞、CNE细胞增殖,促进其凋亡,且呈剂量依赖性（P均〈0.05）;BA可抑制HMEC细胞增殖,减弱迁移能力及血管形成能力,且呈剂量依赖性（P均〈0.05）。结论 BA可抑制人肝癌细胞、鼻咽癌细胞增殖及肿瘤组织血管生成。...

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Bibliographic Details
Published in山东医药 Vol. 56; no. 3; pp. 5 - 7
Main Author 黄荷云 周尧远 张荣军 蔡刚明 顾晓波 潘栋辉 蒋孟军
Format Magazine Article
LanguageChinese
Published 卫生部核医学重点实验室 2016
江苏省分子核医学重点实验室%南京医科大学附属无锡人民医院
江苏省原子医学研究所,江苏无锡214063
Subjects
人肝癌细胞
人血管内皮细胞
人鼻咽癌细胞
白桦酸
human hepatocellular carcinoma cells
human vascular endothelial cells
白桦酸
人鼻咽癌细胞
Betulinic acid
human nasopharyngeal carcinoma cells
人肝癌细胞
人血管内皮细胞
Online AccessGet full text
ISSN1002-266X
DOI10.3969/j.issn.1002-266X.2016.03.002

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Summary:目的观察白桦酸（BA）对肿瘤细胞增殖及组织血管生成的影响。方法培养人肝癌细胞株Bel-7402、人鼻咽癌细胞株CNE、人血管内皮细胞株HMEC,分别以不同浓度的BA干预,比较Bel-7402细胞和CNE细胞增殖抑制率、凋亡率,并比较HMEC细胞增殖抑制率、迁移能力、血管形成能力。结果 BA可抑制Bel-7402细胞、CNE细胞增殖,促进其凋亡,且呈剂量依赖性（P均〈0.05）;BA可抑制HMEC细胞增殖,减弱迁移能力及血管形成能力,且呈剂量依赖性（P均〈0.05）。结论 BA可抑制人肝癌细胞、鼻咽癌细胞增殖及肿瘤组织血管生成。
Bibliography:37-1156/R
Betulinic acid; human hepatocellular carcinoma cells; human nasopharyngeal carcinoma cells; human vascular endothelial cells
Objective To observe the effects of Betulinic acid （BA） in vitro on the proliferation and angiogenesis of tumor cells. Methods The human hepatocellular carcinoma cells （ Bel-7402）, human nasopharyngeal carcinoma cells （CNE） and human microcapillary endothelial cells （HMEC） were intervened by different concentrations of BA. The prolif- eration inhibition rates and apoptosis rates of Bel-7402 cells and CNE cells were compared. In addition, the proliferation in- hibition rate, migratory ability and angiogenesis of HMEC cells were compared. Results BA inhibited the proliferation and promoted the apoptosis of Bel-7402 cells and CNE cells, which were in a dose-dependent manner （ all P 〈 0.05）. BA also inhibited the proliferation and reduced the migratory ability and angiogenesis with a dose-dependent manner （ all P 〈 0.05）. Conclusion BA can inhibit the proliferation and angiogenesis
ISSN:1002-266X
DOI:10.3969/j.issn.1002-266X.2016.03.002