Watasemycins A and B, New Antibiotics Produced by Streptomyces sp. TP-A0597

• Published in: Journal of antibiotics Vol. 55; no. 3; pp. 249 - 255
• Main Authors: SASAKI, TOMOMITSU, IGARASHI, YASUHIRO, SAITO, NORIKO, FURUMAI, TAMOTSU
• Format: Journal Article
• Language: English
• Published: TOKYO JAPAN ANTIBIOTICS RESEARCH ASSOCIATION 2002; JAPAN ANTIBIOT RES ASSN; Japan Antibiotics Research Association
• Subjects: Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - isolation & purification; Anti-Bacterial Agents - pharmacology; Antibiotics (antibacterial agents, antifungal agents); Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Applied microbiology; Biological and medical sciences; Biotechnology & Applied Microbiology; Fundamental and applied biological sciences. Psychology; Gram-Negative Bacteria - drug effects; Gram-Positive Bacteria - drug effects; Immunology; Life Sciences & Biomedicine; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Microbiology; Microscopy, Electron, Scanning; Pharmacology & Pharmacy; Science & Technology; Seawater - microbiology; Streptomyces - classification; Streptomyces - metabolism; Streptomyces - ultrastructure; Thiazoles - chemistry; Thiazoles - isolation & purification; Thiazoles - pharmacology; Thiazolidines; Yeasts - drug effects; TETROCARCIN CLASS; MEMBERS; ARISOSTATIN-A; MICROMONOSPORA SP TP-A0316; Streptomycetaceae; Isomerization; Streptomyces; Fermentation; In vitro; Biological activity; Actinomycetales; Antibiotic; Antifungal agent; Microorganism culture; Bacteria; Actinomycetes; Antibacterial agent; Physicochemical properties; Structural analysis
• ISSN: 0021-8820; 1881-1469
• DOI: 10.7164/antibiotics.55.249

Two novel antibiotics, watasemycins A and B, were isolated from the fermentation broth of an actinomycete strain. The producing strain TP-A0597 was isolated from the seawater sample collected in Toyama Bay, Japan and identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification and spectroscopic analyses identified that they were new analogs of thiazostatins. Watasemycin possesses a methyl group at 5'-position of thiazostatin instead of a hydrogen atom. Watasemycins showed antibiotic activity against Gram-positive and negative bacteria and yeast.