Chaperone-mediated autophagy: selectivity pays off

Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by whi...

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Bibliographic Details
Published inTrends in endocrinology and metabolism Vol. 21; no. 3; pp. 142 - 150
Main Author Cuervo, Ana Maria
Format Journal Article
LanguageEnglish
Published Cambridge, MA Elsevier Ltd 01.03.2010
Cell Press
Subjects
Animals
Autophagy - genetics
Autophagy - physiology
Biological and medical sciences
Endocrinology & Metabolism
Fundamental and applied biological sciences. Psychology
Humans
Lysosomes - metabolism
Models, Biological
Molecular Chaperones - genetics
Molecular Chaperones - metabolism
Vertebrates: endocrinology
Chaperone
Selectivity
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Summary:Degradation of intracellular components in lysosomes, generically known as autophagy, can occur through different pathways. This review discusses chaperone-mediated autophagy (CMA), a type of autophagy set apart from other autophagic pathways owing to its selectivity and distinctive mechanism by which substrates reach the lysosomal lumen. CMA participates in quality control and provides energy to cells under persistently poor nutritional conditions. Alterations in CMA have recently been shown to underlie some severe human disorders for which the decline with age in the activity of this pathway might become a major aggravating factor. Prevention of the age-dependent decline in CMA has major beneficial effects on cellular and organ homeostasis and function, revealing that CMA is an essential component of the anti-aging fight.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2009.10.003