The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox
Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand,...
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| Published in | Balkan Medical Journal Vol. 35; no. 3; pp. 225 - 232 |
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| Main Authors | , , , , |
| Format | Journal Article Book Review |
| Language | English Turkish |
| Published |
Turkey
Galenos Yayinevi Tic. Ltd
01.05.2018
Trakya Üniversitesi Aves Yayincilik Ltd. STI Galenos Publishing Galenos Publishing House |
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| Abstract | Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease. |
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| AbstractList | Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease. Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease. Keywords: Cardiovascular disease, heart, inflammatory markers, osteoprotegerin |
| Audience | Academic |
| Author | Altun, Armağan Pandi-Perumal, Seithikurippu Ratnas Özkalaycı, Flora Gülmez, Öykü Uğur-Altun, Betül |
| AuthorAffiliation | Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalı, Endokrinoloji ve Metabolizma Bilim Dalı Dahili Tıp Bilimleri Bölümü, Kardiyoloji Anabilim Dalı Kardiyoloji Anabilim Dalı |
| AuthorAffiliation_xml | – name: Kardiyoloji Anabilim Dalı – name: Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Anabilim Dalı, Endokrinoloji ve Metabolizma Bilim Dalı – name: Dahili Tıp Bilimleri Bölümü, Kardiyoloji Anabilim Dalı – name: 2 Department of Endocrinology and Metabolism, Başkent University İstanbul Hospital, İstanbul, Turkey – name: 1 Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey – name: 3 Somnogen Canada Inc., College Street, Toronto, Canada |
| Author_xml | – sequence: 1 givenname: Flora surname: Özkalaycı fullname: Özkalaycı, Flora organization: Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey – sequence: 2 givenname: Öykü surname: Gülmez fullname: Gülmez, Öykü organization: Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey – sequence: 3 givenname: Betül surname: Uğur-Altun fullname: Uğur-Altun, Betül organization: Department of Endocrinology and Metabolism, Başkent University İstanbul Hospital, İstanbul, Turkey – sequence: 4 givenname: Seithikurippu Ratnas surname: Pandi-Perumal fullname: Pandi-Perumal, Seithikurippu Ratnas organization: Somnogen Canada Inc., College Street, Toronto, Canada – sequence: 5 givenname: Armağan surname: Altun fullname: Altun, Armağan organization: Department of Cardiology, Başkent University İstanbul Hospital, İstanbul, Turkey |
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| Keywords | inflammatory markers Cardiovascular disease osteoprotegerin heart |
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| SubjectTerms | Age Amino acids Apoptosis Atherosclerosis Calcification Cardiovascular disease Cardiovascular diseases Coronary vessels Cytokine receptors Diabetes Diabetic retinopathy Gender differences Glycoproteins Growth factors heart Hemodialysis inflammatory markers Invited Review Kinases Ligands Metabolism Mortality Osteoporosis osteoprotegerin Pathogenesis Proteins Signal transduction Studies Tıp Tumor necrosis factor-TNF Women |
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| Title | The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox |
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