The Role of Osteoprotegerin as a Cardioprotective Versus Reactive Inflammatory Marker: the Chicken or the Egg Paradox

• Published in: Balkan Medical Journal Vol. 35; no. 3; pp. 225 - 232
• Main Authors: Özkalaycı, Flora, Gülmez, Öykü, Uğur-Altun, Betül, Pandi-Perumal, Seithikurippu Ratnas, Altun, Armağan
• Format: Journal Article Book Review
• Language: English; Turkish
• Published: Turkey Galenos Yayinevi Tic. Ltd 01.05.2018; Trakya Üniversitesi; Aves Yayincilik Ltd. STI; Galenos Publishing; Galenos Publishing House
• Subjects: Age; Amino acids; Apoptosis; Atherosclerosis; Calcification; Cardiovascular disease; Cardiovascular diseases; Coronary vessels; Cytokine receptors; Diabetes; Diabetic retinopathy; Gender differences; Glycoproteins; Growth factors; heart; Hemodialysis; inflammatory markers; Invited Review; Kinases; Ligands; Metabolism; Mortality; Osteoporosis; osteoprotegerin; Pathogenesis; Proteins; Signal transduction; Studies; Tıp; Tumor necrosis factor-TNF; Women; Türkiye; Edirne; Canada; Turkey; inflammatory markers; Cardiovascular disease; osteoprotegerin; heart
• ISSN: 2146-3123; 2146-3131
• DOI: 10.4274/balkanmedj.2018.0579

Cardiovascular disease is one of the most frequent causes of mortality and morbidity worldwide. Several variables have been identified as risk factors for cardiovascular disease. Recently, the role of receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and the osteoprotegerin system has been recognized as more important in the pathogenesis of cardiovascular disease. Besides their roles in the regulation of bone resorption, these molecules have been reported to be associated with the pathophysiology of cardiovascular disease. There are conflicting data regarding the impact of osteoprotegerin, a glycoprotein with a regulatory role in the cardiovascular system. The aim of this review is to discuss the current knowledge and the role of osteoprotegerin in cardiovascular disease.