Monitoring of PAEMs and beta-agonists in urine for a small group of experimental subjects and PAEs and beta-agonists in drinking water consumed by the same subjects

• Published in: Journal of hazardous materials Vol. 277; pp. 169 - 179
• Main Authors: Liou, Saou-Hsing, Yang, Gordon C.C., Wang, Chih-Lung, Chiu, Yu-Han
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier B.V 30.07.2014; Elsevier
• Subjects: Adrenergic beta-Agonists - urine; Age; Applied sciences; Beta-agonists; Categories; Consumption; Drinking water; Drinking Water - analysis; Drinking Water - chemistry; Drinking water and swimming-pool water. Desalination; Environmental Monitoring; Esters; Exact sciences and technology; Female; females; Human; Humans; LC–MS/MS; Male; males; Metabolites; monitoring; Phthalate ester metabolites; Phthalate esters; phthalates; Phthalic Acids - urine; Pollution; principal component analysis; ractopamine; Spectrometry, Mass, Electrospray Ionization; Taiwan; Tandem Mass Spectrometry; Urine; Water Pollutants, Chemical - urine; Water treatment and pollution; Taiwan; Urine; Phthalate esters; Beta-agonists; Phthalate ester metabolites; LC–MS/MS; Human; Drinking water; LC-MS/MS; Surveillance; Loading; Metabolite; Degradation product; Principal component analysis
• ISSN: 0304-3894; 1873-3336; 1873-3336
• DOI: 10.1016/j.jhazmat.2014.02.024

•Urinary metabolites of DnBP and DEHP were the main PAEMs found in this study.•Mean concentrations of main urinary PAEMs were higher for the group of older subjects.•Mean concentrations of main urinary PAEMs were of no significant difference between sexes.•Age effect on concentrations of urinary PAEMs was more significant as compared with gender effect.•Ractopamine and salbutamol were not in both human urine and drinking water samples collected. This 5-month study contains two parts: (1) to monitor the concentrations of 11 phthalate esters metabolites (PAEMs) and two beta-agonists in human urine samples collected from a small group of consented participants including 16 females and five males; and (2) to analyze the residues of phthalate esters (PAEs) and beta-agonists in various categories of drinking water consumed by the same group of subjects. Each category of human urine and drinking water had 183 samples of its own. The analytical results showed that nine PAEMs were detected in human urine and eight PAEs were detected in drinking water samples. It was found that average concentrations of PAEMs increased as the age increased, but no significant difference between sexes. Further, using the principal component analysis, the loadings of age effect were found to be two times greater than that of gender effect in terms of four DEHP metabolites. Regarding beta-agonists of concern (i.e., ractopamine and salbutamol), they were neither detected in human urine nor drinking water samples in this study.