Syntheses and Antiviral Effects of 3-Amino-6-alkyl-as-triazin-5-ol Derivatives

The thirteen compounds of amidinohydrazone of α-oxocarboxylic acid and 3-amino-6-alkyl-as-triazin-5-ol were synthesized and tested as to their antiviral activity. Only amidinohydrazone of 2-oxovaleric acid was found effective on common cold virus. Also, it was revealed that the possible existence of...

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Published inChemical & pharmaceutical bulletin Vol. 12; no. 1; pp. 100 - 103
Main Authors Ueda, Takeo, Furukawa, Mitsuru
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.01.1964
Japan Science and Technology Agency
Subjects
Amidines
Antiviral Agents
Chemistry, Pharmaceutical
Heterocyclic Compounds
Old Medline
Orthomyxoviridae
Pharmacology
Rhinovirus
Triazines
ANTIVIRAL AGENTS
CHEMISTRY, PHARMACEUTICAL
INFLUENZA VIRUSES
AMIDINES
PHARMACOLOGY
EXPERIMENTAL LAB STUDY
RHINOVIRUS
TRIAZINES
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Summary:The thirteen compounds of amidinohydrazone of α-oxocarboxylic acid and 3-amino-6-alkyl-as-triazin-5-ol were synthesized and tested as to their antiviral activity. Only amidinohydrazone of 2-oxovaleric acid was found effective on common cold virus. Also, it was revealed that the possible existence of the tautomers of 3-amino-6-alkyl-as-triazin-5-ol in the ground state should be in form of keto and imino.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.12.100