Schizophrenia from a neural circuitry perspective: advancing toward rational pharmacological therapies

Schizophrenia is a severe disorder that disrupts the function of multiple brain systems, resulting in impaired social and occupational functioning. The etiology and pathogenesis of schizophrenia appear to involve the interplay of a potentially large number of genetic liabilities and adverse environm...

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Bibliographic Details
Published inThe Journal of clinical investigation Vol. 119; no. 4; pp. 706 - 716
Main Authors Lewis, David A, Sweet, Robert A
Format Journal Article
LanguageEnglish
Published United States American Society for Clinical Investigation 01.04.2009
Subjects
Auditory Cortex - physiopathology
Biomedical research
Cerebral Cortex - physiopathology
Child development
Disease
Dopamine - physiology
Etiology
Genes
Genetic aspects
Humans
Illnesses
Models, Neurological
Nerve Net - physiopathology
Neurons
Pathogenesis
Pathophysiology
Physiological aspects
Prefrontal Cortex - physiopathology
Psychosis
Review
Risk factors
Schizophrenia
Schizophrenia - drug therapy
Schizophrenia - etiology
Schizophrenia - physiopathology
United States
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Summary:Schizophrenia is a severe disorder that disrupts the function of multiple brain systems, resulting in impaired social and occupational functioning. The etiology and pathogenesis of schizophrenia appear to involve the interplay of a potentially large number of genetic liabilities and adverse environmental events that disrupt brain developmental pathways. In this Review, we discuss a strategy for determining how particular common and core clinical features of the illness are associated with pathophysiology in certain circuits of the cerebral cortex. The identification of molecular alterations in these circuits is providing critical insights for the rational development of new therapeutic interventions.
ISSN:0021-9738
1558-8238
DOI:10.1172/jci37335