A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of...

Full description

Saved in:
Bibliographic Details
Published inNature genetics Vol. 43; no. 12; pp. 1215 - 1218
Main Authors Shi, Yongyong, Hu, Zhibin, Wu, Chen, Dai, Juncheng, Li, Huizhang, Dong, Jing, Wang, Meilin, Miao, Xiaoping, Zhou, Yifeng, Lu, Feng, Zhang, Hanze, Hu, Lingmin, Jiang, Yue, Li, Zhiqiang, Chu, Minjie, Ma, Hongxia, Chen, Jiaping, Jin, Guangfu, Tan, Wen, Wu, Tangchun, Zhang, Zhengdong, Lin, Dongxin, Shen, Hongbing
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.12.2011
Nature Publishing Group
Subjects
631/208/205/2138
631/208/727/2000
631/67/2324
692/699/67/1504/1829
Adult
Aged
Agriculture
AMP-Activated Protein Kinases - genetics
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Case-Control Studies
Chromosomes, Human, Pair 3 - genetics
Chromosomes, Human, Pair 5 - genetics
Confidence intervals
Development and progression
Disease susceptibility
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Gene Function
Genetic aspects
Genetic Loci
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Genomes
Health care
Human Genetics
Humans
letter
Male
Medical sciences
Middle Aged
Nerve Tissue Proteins - genetics
Odds Ratio
Pathogenesis
Polymorphism, Single Nucleotide
Public health
R&D
Receptors, Prostaglandin E, EP4 Subtype - genetics
Research & development
Risk factors
Sample size
Single nucleotide polymorphisms
Stomach cancer
Stomach Neoplasms - genetics
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Studies
Transcription Factors - genetics
Tumors
China
Digestive diseases
Identification
Malignant tumor
Locus
Stomach cancer
Cancer
Gastric disease
Online AccessGet full text

Cover

Abstract Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1 ; odds ratio (OR) = 1.41; P = 7.6 × 10 −29 ) and 3q13.31 (rs9841504 in ZBTB20 ; OR = 0.76; P = 1.7 × 10 −9 ). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
AbstractList Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 x 10 super(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 x 10 super(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1 ; odds ratio (OR) = 1.41; P = 7.6 × 10 −29 ) and 3q13.31 (rs9841504 in ZBTB20 ; OR = 0.76; P = 1.7 × 10 −9 ). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10(-29)) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 × 10^sup -29^) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 × 10^sup -9^). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population. [PUBLICATION ABSTRACT]
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rsl 3361707 in the region including PTGER4 and PRKAA1; odds ratio (OR) = 1.41; P = 7.6 x [10.sup.-29]) and 3q13.31 (rs9841504 in ZBTB20; OR = 0.76; P = 1.7 x [10.sup.-9]). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.
Audience Academic
Author Zhang, Hanze
Hu, Zhibin
Lin, Dongxin
Ma, Hongxia
Wang, Meilin
Miao, Xiaoping
Chu, Minjie
Hu, Lingmin
Shi, Yongyong
Jiang, Yue
Shen, Hongbing
Jin, Guangfu
Zhang, Zhengdong
Wu, Tangchun
Wu, Chen
Dai, Juncheng
Li, Zhiqiang
Li, Huizhang
Tan, Wen
Dong, Jing
Zhou, Yifeng
Lu, Feng
Chen, Jiaping
Author_xml – sequence: 1
  givenname: Yongyong
  surname: Shi
  fullname: Shi, Yongyong
  email: shiyongyong@gmail.com
  organization: Bio-X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University
– sequence: 2
  givenname: Zhibin
  surname: Hu
  fullname: Hu, Zhibin
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, State Key Laboratory of Reproductive Medicine, Nanjing Medical University
– sequence: 3
  givenname: Chen
  surname: Wu
  fullname: Wu, Chen
  organization: Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
– sequence: 4
  givenname: Juncheng
  surname: Dai
  fullname: Dai, Juncheng
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 5
  givenname: Huizhang
  surname: Li
  fullname: Li, Huizhang
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 6
  givenname: Jing
  surname: Dong
  fullname: Dong, Jing
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 7
  givenname: Meilin
  surname: Wang
  fullname: Wang, Meilin
  organization: Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University
– sequence: 8
  givenname: Xiaoping
  surname: Miao
  fullname: Miao, Xiaoping
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
– sequence: 9
  givenname: Yifeng
  surname: Zhou
  fullname: Zhou, Yifeng
  organization: Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, Medical College, Soochow University
– sequence: 10
  givenname: Feng
  surname: Lu
  fullname: Lu, Feng
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 11
  givenname: Hanze
  surname: Zhang
  fullname: Zhang, Hanze
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 12
  givenname: Lingmin
  surname: Hu
  fullname: Hu, Lingmin
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 13
  givenname: Yue
  surname: Jiang
  fullname: Jiang, Yue
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 14
  givenname: Zhiqiang
  surname: Li
  fullname: Li, Zhiqiang
  organization: Bio-X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University
– sequence: 15
  givenname: Minjie
  surname: Chu
  fullname: Chu, Minjie
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 16
  givenname: Hongxia
  surname: Ma
  fullname: Ma, Hongxia
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University
– sequence: 17
  givenname: Jiaping
  surname: Chen
  fullname: Chen, Jiaping
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
– sequence: 18
  givenname: Guangfu
  surname: Jin
  fullname: Jin, Guangfu
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University
– sequence: 19
  givenname: Wen
  surname: Tan
  fullname: Tan, Wen
  organization: Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
– sequence: 20
  givenname: Tangchun
  surname: Wu
  fullname: Wu, Tangchun
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
– sequence: 21
  givenname: Zhengdong
  surname: Zhang
  fullname: Zhang, Zhengdong
  organization: Department of Occupational Medicine and Environmental Health, School of Public Health, Nanjing Medical University
– sequence: 22
  givenname: Dongxin
  surname: Lin
  fullname: Lin, Dongxin
  email: lindx72@cicams.ac.cn
  organization: Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Cancer Institute & Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
– sequence: 23
  givenname: Hongbing
  surname: Shen
  fullname: Shen, Hongbing
  email: hbshen@njmu.edu.cn
  organization: Department of Epidemiology and Biostatistics, Ministry of Education Key Laboratory for Modern Toxicology, School of Public Health, Nanjing Medical University, Section of Clinical Epidemiology, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, Cancer Center, Nanjing Medical University, State Key Laboratory of Reproductive Medicine, Nanjing Medical University
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25285509$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/22037551$$D View this record in MEDLINE/PubMed
BookMark eNqN0ltrFDEUAOAgFduu-hMkWLyBs-YyyWQel-KlUCh4ew2ZTGZImc1sk4x1_71n3dWyq4jkISF8OeRcTtFRGIND6DElc0q4ehP6eV2pe-iEilIWtKLqCM5E0qIkXB6j05SuCaFlSdQDdMwY4ZUQ9AR9W-DehXHpilvfOmxSGq032Y8Bpzy1awy3IfvOu4SDu8VpStatsm_84PMaD6BxN0YM3ymsia03uDcpR2-xNcG6iE3G_IbyOafYhBaLFZzpQ3S_M0Nyj3b7DH159_bz-Yfi8ur9xfnisrCS0FzUtO5YxXnLXSWYtFRSw2QlW1YT0vLaSNVUojGNYbxWgkumrFSWGNkpVzHKZ-jFNu4qjjeTS1kvPSQwDCa4cUq6JlIIiCVBvvynhCqXijEK35mhpwf0epxigDx0TZmAqosa0NkW9WZw2oduzNHYTUy9YFXJmOJMgJr_RcFq3dJbaHHn4X7vwau9B2Cy-557M6WkLz59_H979XXfPtnlNDVL1-pV9EsT1_rXpAB4tgMmWTN0Ebrr050TTAlBNnk_3zobx5Si634TSjZFVDr0GkYV4OsDaH3-OXlQAj_8yXedTBAv9C7eFf1A_gCe0--J
CODEN NGENEC
CitedBy_id crossref_primary_10_1002_ijc_28415
crossref_primary_10_3390_biom14020192
crossref_primary_10_1016_j_ebiom_2023_104616
crossref_primary_10_18632_oncotarget_22172
crossref_primary_10_1038_jhg_2012_158
crossref_primary_10_18632_oncotarget_4231
crossref_primary_10_1002_cncr_28792
crossref_primary_10_1016_j_tig_2012_01_003
crossref_primary_10_1016_j_gene_2015_04_081
crossref_primary_10_1002_ijc_31381
crossref_primary_10_1038_nrclinonc_2013_170
crossref_primary_10_1111_cas_13815
crossref_primary_10_1002_ijc_31839
crossref_primary_10_1007_s00761_020_00806_6
crossref_primary_10_1371_journal_pone_0092911
crossref_primary_10_1016_j_bbcan_2015_01_004
crossref_primary_10_1186_s13046_023_02654_9
crossref_primary_10_1371_journal_pone_0132797
crossref_primary_10_7314_APJCP_2014_15_10_4207
crossref_primary_10_2147_PGPM_S258672
crossref_primary_10_18632_oncotarget_9025
crossref_primary_10_1371_journal_pone_0050856
crossref_primary_10_1007_s11033_013_2682_4
crossref_primary_10_3390_ijms160716263
crossref_primary_10_1186_s40064_015_1005_8
crossref_primary_10_18632_aging_103822
crossref_primary_10_1038_s41388_021_01981_5
crossref_primary_10_5301_ijbm_5000270
crossref_primary_10_1186_s12885_018_4818_3
crossref_primary_10_18632_oncotarget_13123
crossref_primary_10_1007_s00204_020_02958_1
crossref_primary_10_1371_journal_pone_0136269
crossref_primary_10_18632_oncotarget_22864
crossref_primary_10_1007_s13277_013_1029_z
crossref_primary_10_1016_j_canlet_2023_216436
crossref_primary_10_1038_nchina_2012_6
crossref_primary_10_7717_peerj_8600
crossref_primary_10_1007_s10120_017_0717_6
crossref_primary_10_1016_j_yexmp_2017_07_004
crossref_primary_10_1158_1055_9965_EPI_11_1176
crossref_primary_10_7314_APJCP_2014_15_19_8035
crossref_primary_10_1038_s41589_018_0131_3
crossref_primary_10_1093_carcin_bgt259
crossref_primary_10_18632_oncotarget_1324
crossref_primary_10_1007_s00439_013_1276_5
crossref_primary_10_1158_1055_9965_EPI_13_1329
crossref_primary_10_3390_cancers14225636
crossref_primary_10_1097_MD_0000000000010302
crossref_primary_10_1093_carcin_bgy151
crossref_primary_10_1371_journal_pone_0088334
crossref_primary_10_1016_j_febslet_2014_10_005
crossref_primary_10_5301_jbm_5000233
crossref_primary_10_5301_jbm_5000231
crossref_primary_10_1016_j_cclet_2016_04_005
crossref_primary_10_1038_ng_3342
crossref_primary_10_1002_jcla_23406
crossref_primary_10_2147_PGPM_S258761
crossref_primary_10_7314_APJCP_2015_16_14_6027
crossref_primary_10_1007_s13277_015_4022_x
crossref_primary_10_1007_s13277_014_2655_9
crossref_primary_10_1158_0008_5472_CAN_23_2397
crossref_primary_10_18632_oncotarget_8888
crossref_primary_10_1016_j_gene_2018_05_093
crossref_primary_10_1038_s41591_020_01223_3
crossref_primary_10_1186_s12944_016_0307_3
crossref_primary_10_1136_gutjnl_2017_315230
crossref_primary_10_1007_s10120_018_0841_y
crossref_primary_10_1089_dna_2012_1615
crossref_primary_10_1093_bioinformatics_btu273
crossref_primary_10_4236_jbm_2017_511009
crossref_primary_10_1016_j_molimm_2014_10_006
crossref_primary_10_1186_s40364_018_0133_z
crossref_primary_10_18632_oncotarget_19355
crossref_primary_10_1042_BSR20202102
crossref_primary_10_3389_fonc_2021_694977
crossref_primary_10_1158_1055_9965_EPI_17_0169
crossref_primary_10_1038_s41598_017_12040_z
crossref_primary_10_3389_fgene_2020_00679
crossref_primary_10_1126_sciadv_aav9778
crossref_primary_10_1186_s12885_019_5355_4
crossref_primary_10_1038_s41388_023_02855_8
crossref_primary_10_1371_journal_pone_0074976
crossref_primary_10_1136_gutjnl_2015_309340
crossref_primary_10_1007_s00204_020_02782_7
crossref_primary_10_1002_ijc_30447
crossref_primary_10_1371_journal_pone_0116979
crossref_primary_10_3390_cancers13040876
crossref_primary_10_1186_s12876_016_0489_1
crossref_primary_10_18632_oncotarget_6124
crossref_primary_10_1371_journal_pone_0139059
crossref_primary_10_3390_cancers13215525
crossref_primary_10_1016_j_celrep_2021_109069
crossref_primary_10_3389_fmicb_2015_00412
crossref_primary_10_1016_j_gene_2014_02_033
crossref_primary_10_3389_fgene_2022_928783
crossref_primary_10_1038_srep11961
crossref_primary_10_3389_fonc_2021_632609
crossref_primary_10_1371_journal_pone_0049308
crossref_primary_10_1016_j_fmre_2022_09_031
crossref_primary_10_1007_s00204_020_02771_w
crossref_primary_10_1136_gutjnl_2013_305178
crossref_primary_10_1001_jamanetworkopen_2024_13708
crossref_primary_10_1002_pmic_201200489
crossref_primary_10_3892_ol_2016_4253
crossref_primary_10_1002_cam4_1612
crossref_primary_10_1007_s10552_012_0110_z
crossref_primary_10_1016_j_ajhg_2012_09_009
crossref_primary_10_1016_j_canlet_2015_06_028
crossref_primary_10_1002_cam4_3354
crossref_primary_10_1371_journal_pone_0068999
crossref_primary_10_1016_S2468_1253_18_30237_1
crossref_primary_10_1002_ccr3_167
crossref_primary_10_1016_j_gene_2017_09_053
crossref_primary_10_18632_aging_203484
crossref_primary_10_1136_gutjnl_2015_309168
crossref_primary_10_1002_cncr_32081
crossref_primary_10_1186_s12881_018_0704_8
crossref_primary_10_1038_s41591_023_02424_2
crossref_primary_10_1002_ijc_29352
crossref_primary_10_1038_nrgastro_2014_143
crossref_primary_10_1007_s11434_012_5633_x
crossref_primary_10_18632_genesandcancer_63
crossref_primary_10_1002_mc_21966
crossref_primary_10_1371_journal_pone_0177504
crossref_primary_10_1371_journal_pone_0117576
crossref_primary_10_1111_ajco_13654
crossref_primary_10_1007_s11684_012_0225_3
crossref_primary_10_1093_carcin_bgt079
crossref_primary_10_1002_humu_22284
crossref_primary_10_1016_j_ebiom_2015_10_028
crossref_primary_10_1016_j_ebiom_2021_103347
crossref_primary_10_1002_mc_22261
crossref_primary_10_1007_s10330_015_0084_x
crossref_primary_10_1002_ijc_28033
crossref_primary_10_1053_j_gastro_2017_02_017
crossref_primary_10_18821_0023_2149_2017_95_7_594_598
crossref_primary_10_3390_ijms15057958
crossref_primary_10_3760_cma_j_issn_0366_6999_20133123
crossref_primary_10_1038_s10038_023_01151_3
crossref_primary_10_1097_CEJ_0000000000000480
crossref_primary_10_2174_1566524020666191227103144
crossref_primary_10_4143_crt_2022_958
crossref_primary_10_4103_jcrt_JCRT_12_19
crossref_primary_10_1111_1759_7714_12281
crossref_primary_10_18632_oncotarget_7137
crossref_primary_10_1097_MD_0000000000008213
crossref_primary_10_3389_fmicb_2020_01548
crossref_primary_10_1186_s13046_023_02611_6
crossref_primary_10_1067_j_cpsurg_2015_08_001
crossref_primary_10_1136_gutjnl_2019_318760
crossref_primary_10_1016_j_ajpath_2012_07_006
crossref_primary_10_1053_j_gastro_2022_01_011
crossref_primary_10_1080_21691401_2019_1670188
crossref_primary_10_4236_jct_2013_41A003
crossref_primary_10_5230_jgc_2020_20_e11
crossref_primary_10_4143_crt_2018_162
crossref_primary_10_1007_s42764_022_00077_y
crossref_primary_10_18632_oncotarget_6853
crossref_primary_10_1038_ejhg_2017_103
crossref_primary_10_1007_s12032_014_0401_1
crossref_primary_10_1111_jcmm_15798
crossref_primary_10_1016_j_ebiom_2018_06_028
crossref_primary_10_1158_1055_9965_EPI_13_1057
crossref_primary_10_1038_ng_2779
crossref_primary_10_18632_oncotarget_11802
crossref_primary_10_1007_s40142_018_0153_x
crossref_primary_10_1126_sciadv_aay5525
crossref_primary_10_3748_wjg_v22_i7_2373
crossref_primary_10_1002_mc_22843
crossref_primary_10_1093_ije_dyv050
crossref_primary_10_1007_s12032_013_0658_9
crossref_primary_10_3233_CBM_181278
crossref_primary_10_1158_1055_9965_EPI_19_0724
crossref_primary_10_1159_000431265
crossref_primary_10_3233_CBM_160574
crossref_primary_10_1136_gutjnl_2015_310612
crossref_primary_10_3390_cancers5010092
crossref_primary_10_1038_srep41737
crossref_primary_10_1007_s11427_013_4464_6
crossref_primary_10_3390_biomedicines12092162
crossref_primary_10_3390_ijms241813763
crossref_primary_10_1038_s10038_018_0501_4
crossref_primary_10_1093_carcin_bgx110
crossref_primary_10_1007_s00439_016_1687_1
crossref_primary_10_1186_s12920_023_01645_1
crossref_primary_10_1038_srep07891
crossref_primary_10_15252_embr_202152707
crossref_primary_10_1002_cam4_926
crossref_primary_10_1038_s41435_021_00146_4
crossref_primary_10_3109_13880209_2015_1055634
crossref_primary_10_1007_s13277_013_1287_9
crossref_primary_10_1089_gtmb_2013_0438
crossref_primary_10_1002_mc_22063
crossref_primary_10_1016_j_omtn_2019_09_034
crossref_primary_10_1111_cas_12399
crossref_primary_10_1002_cam4_1038
crossref_primary_10_1111_cas_12042
crossref_primary_10_3389_fgene_2014_00290
crossref_primary_10_1038_srep07080
crossref_primary_10_1016_S1470_2045_13_70550_3
crossref_primary_10_1016_j_mrrev_2013_09_002
crossref_primary_10_1097_CEJ_0000000000000724
crossref_primary_10_1080_21691401_2019_1657876
crossref_primary_10_1093_carcin_bgad080
crossref_primary_10_1371_journal_pone_0176045
crossref_primary_10_1186_s40170_021_00269_2
crossref_primary_10_1038_s41598_020_64467_6
crossref_primary_10_1152_ajpgi_00209_2020
crossref_primary_10_1093_carcin_bgt094
crossref_primary_10_1002_cam4_1719
Cites_doi 10.1073/pnas.0800647105
10.1086/519795
10.1093/jnci/89.17.1277
10.1038/ng1847
10.1038/nrc2676
10.1371/journal.pgen.0030058
10.1002/ijc.20616
10.1038/ng.152
10.1093/carcin/bgr051
10.1016/S0022-2143(02)00023-9
10.1038/nrc703
10.1038/ng.649
10.1006/bbrc.2001.4689
10.1002/sim.1186
10.1038/ng.723
10.1038/ng.648
10.1002/mc.20565
10.1002/ijc.25228
10.1038/nm872
10.1074/jbc.R600038200
10.1038/ng1333
10.1093/jn/132.11.3467S
ContentType Journal Article
Copyright Springer Nature America, Inc. 2011
2015 INIST-CNRS
COPYRIGHT 2011 Nature Publishing Group
Copyright Nature Publishing Group Dec 2011
Copyright_xml – notice: Springer Nature America, Inc. 2011
– notice: 2015 INIST-CNRS
– notice: COPYRIGHT 2011 Nature Publishing Group
– notice: Copyright Nature Publishing Group Dec 2011
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
IOV
ISR
3V.
7QL
7QP
7QR
7SS
7T7
7TK
7TM
7U9
7X7
7XB
88A
88E
8AO
8C1
8FD
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9.
LK8
M0S
M1P
M2O
M7N
M7P
MBDVC
P64
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
Q9U
RC3
7X8
DOI 10.1038/ng.978
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Gale In Context: Opposing Viewpoints
Gale In Context: Science
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Entomology Abstracts (Full archive)
Industrial and Applied Microbiology Abstracts (Microbiology A)
Neurosciences Abstracts
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Biology Database (Alumni Edition)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database
Technology Research Database
ProQuest SciTech Collection
ProQuest Natural Science Collection
ProQuest Hospital Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest One Sustainability (subscription)
ProQuest Central UK/Ireland
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
Research Library Prep
AIDS and Cancer Research Abstracts
SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
Health & Medical Collection (Alumni)
Medical Database
Research Library
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Research Library (Corporate)
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
ProQuest Central Basic
Genetics Abstracts
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Neurosciences Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Biology Journals (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest Research Library
ProQuest Public Health
ProQuest Central Basic
ProQuest SciTech Collection
ProQuest Medical Library
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic
Genetics Abstracts

MEDLINE
Research Library Prep
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 3
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Agriculture
Biology
Public Health
EISSN 1546-1718
EndPage 1218
ExternalDocumentID 2546687441
A274228325
22037551
25285509
10_1038_ng_978
Genre Research Support, Non-U.S. Gov't
Journal Article
GeographicLocations China
GeographicLocations_xml – name: China
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
123
29M
2FS
36B
39C
3O-
3V.
4.4
53G
5BI
5M7
5RE
5S5
70F
7X7
85S
88A
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8R4
8R5
AAEEF
AAHBH
AARCD
AAYOK
AAYZH
AAZLF
ABAWZ
ABCQX
ABDBF
ABDPE
ABEFU
ABJNI
ABLJU
ABOCM
ABTAH
ABUWG
ACBWK
ACGFO
ACGFS
ACIWK
ACMJI
ACNCT
ACPRK
ACUHS
ADBBV
ADFRT
AENEX
AEUYN
AFBBN
AFFNX
AFKRA
AFRAH
AFSHS
AGAYW
AGCDD
AGHTU
AHBCP
AHMBA
AHOSX
AHSBF
AIBTJ
ALFFA
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
ARMCB
ASPBG
AVWKF
AXYYD
AZFZN
AZQEC
B0M
BBNVY
BENPR
BHPHI
BKKNO
BPHCQ
BVXVI
CCPQU
CS3
DB5
DU5
DWQXO
EAD
EAP
EBC
EBD
EBS
EE.
EJD
EMB
EMK
EMOBN
EPL
ESX
EXGXG
F5P
FEDTE
FQGFK
FSGXE
FYUFA
GNUQQ
GUQSH
GX1
HCIFZ
HMCUK
HVGLF
HZ~
IAO
IH2
IHR
INH
INR
IOV
ISR
ITC
L7B
LGEZI
LK8
LOTEE
M0L
M1P
M2O
M7P
MVM
N9A
NADUK
NNMJJ
NXXTH
ODYON
P2P
PKN
PQQKQ
PROAC
PSQYO
Q2X
RIG
RNS
RNT
RNTTT
RVV
SHXYY
SIXXV
SJN
SNYQT
SOJ
SV3
TAOOD
TBHMF
TDRGL
TN5
TSG
TUS
UKHRP
VQA
X7M
XJT
XOL
Y6R
YHZ
ZGI
ZXP
ZY4
~8M
~KM
AAYXX
ABFSG
ACMFV
ACSTC
AETEA
AFANA
ALPWD
ATHPR
CITATION
PHGZM
PHGZT
AEZWR
AFHIU
AHWEU
AIXLP
IQODW
NFIDA
PJZUB
PPXIY
PQGLB
CGR
CUY
CVF
ECM
EIF
NPM
AEIIB
PMFND
7QL
7QP
7QR
7SS
7T7
7TK
7TM
7U9
7XB
8FD
8FK
C1K
FR3
H94
K9.
M7N
MBDVC
P64
PKEHL
PQEST
PQUKI
PRINS
Q9U
RC3
7X8
ID FETCH-LOGICAL-c601t-919f2733d3e7526c161a2676d2900d39a68b75baba239853628c68c0a6f8e7213
IEDL.DBID 7X7
ISSN 1061-4036
1546-1718
IngestDate Thu Jul 10 17:45:24 EDT 2025
Fri Jul 11 05:38:29 EDT 2025
Fri Jul 25 08:51:57 EDT 2025
Tue Jun 17 22:07:05 EDT 2025
Tue Jun 10 21:05:00 EDT 2025
Fri Jun 27 05:56:21 EDT 2025
Fri Jun 27 05:46:16 EDT 2025
Mon Jul 21 06:04:42 EDT 2025
Mon Jul 21 09:14:59 EDT 2025
Tue Jul 01 01:50:09 EDT 2025
Thu Apr 24 22:50:29 EDT 2025
Fri Feb 21 02:37:42 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 12
Keywords Digestive diseases
Identification
Malignant tumor
Locus
Stomach cancer
Cancer
Gastric disease
Language English
License http://www.springer.com/tdm
CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c601t-919f2733d3e7526c161a2676d2900d39a68b75baba239853628c68c0a6f8e7213
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
content type line 23
PMID 22037551
PQID 912510659
PQPubID 33429
PageCount 4
ParticipantIDs proquest_miscellaneous_906559006
proquest_miscellaneous_1034822127
proquest_journals_912510659
gale_infotracmisc_A274228325
gale_infotracacademiconefile_A274228325
gale_incontextgauss_ISR_A274228325
gale_incontextgauss_IOV_A274228325
pubmed_primary_22037551
pascalfrancis_primary_25285509
crossref_primary_10_1038_ng_978
crossref_citationtrail_10_1038_ng_978
springer_journals_10_1038_ng_978
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2011-12-01
PublicationDateYYYYMMDD 2011-12-01
PublicationDate_xml – month: 12
  year: 2011
  text: 2011-12-01
  day: 01
PublicationDecade 2010
PublicationPlace New York
PublicationPlace_xml – name: New York
– name: New York, NY
– name: United States
PublicationTitle Nature genetics
PublicationTitleAbbrev Nat Genet
PublicationTitleAlternate Nat Genet
PublicationYear 2011
Publisher Nature Publishing Group US
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group US
– name: Nature Publishing Group
References Peek, Blaser (CR4) 2002; 2
Sugimoto, Narumiya (CR9) 2007; 282
Gammon (CR2) 1997; 89
Purdue (CR19) 2011; 43
Okuyama (CR11) 2002; 140
Zhang (CR18) 2011; 32
Zhang (CR14) 2001; 282
Abnet (CR6) 2010; 42
Xie (CR13) 2008; 105
Tran (CR1) 2005; 113
Mayne, Navarro (CR3) 2002; 132
Libioulle (CR12) 2007; 3
Sakamoto (CR15) 2008; 40
Freedman (CR7) 2004; 36
Kabashima (CR10) 2003; 9
Wu (CR16) 2009; 48
Lu (CR17) 2010; 127
Price (CR20) 2006; 38
Wang (CR5) 2010; 42
Shackelford, Shaw (CR8) 2009; 9
Purcell (CR21) 2007; 81
Higgins, Thompson (CR22) 2002; 21
LD Wang (BFng978_CR5) 2010; 42
H Sakamoto (BFng978_CR15) 2008; 40
ST Mayne (BFng978_CR3) 2002; 132
C Libioulle (BFng978_CR12) 2007; 3
GD Tran (BFng978_CR1) 2005; 113
JP Higgins (BFng978_CR22) 2002; 21
H Zhang (BFng978_CR18) 2011; 32
C Wu (BFng978_CR16) 2009; 48
S Purcell (BFng978_CR21) 2007; 81
MD Gammon (BFng978_CR2) 1997; 89
K Kabashima (BFng978_CR10) 2003; 9
T Okuyama (BFng978_CR11) 2002; 140
Y Lu (BFng978_CR17) 2010; 127
AL Price (BFng978_CR20) 2006; 38
Y Sugimoto (BFng978_CR9) 2007; 282
Z Xie (BFng978_CR13) 2008; 105
CC Abnet (BFng978_CR6) 2010; 42
ML Freedman (BFng978_CR7) 2004; 36
W Zhang (BFng978_CR14) 2001; 282
MP Purdue (BFng978_CR19) 2011; 43
DB Shackelford (BFng978_CR8) 2009; 9
RM Peek Jr. (BFng978_CR4) 2002; 2
17447842 - PLoS Genet. 2007 Apr 20;3(4):e58
15052270 - Nat Genet. 2004 Apr;36(4):388-93
17329241 - J Biol Chem. 2007 Apr 20;282(16):11613-7
20729852 - Nat Genet. 2010 Sep;42(9):764-7
12421872 - J Nutr. 2002 Nov;132(11 Suppl):3467S-3470S
11352661 - Biochem Biophys Res Commun. 2001 Apr 13;282(4):1067-73
11902583 - Nat Rev Cancer. 2002 Jan;2(1):28-37
12111919 - Stat Med. 2002 Jun 15;21(11):1539-58
17701901 - Am J Hum Genet. 2007 Sep;81(3):559-75
12228765 - J Lab Clin Med. 2002 Aug;140(2):92-102
9293918 - J Natl Cancer Inst. 1997 Sep 3;89(17):1277-84
20729853 - Nat Genet. 2010 Sep;42(9):759-63
19554573 - Mol Carcinog. 2009 Dec;48(12):1131-8
16862161 - Nat Genet. 2006 Aug;38(8):904-9
18488030 - Nat Genet. 2008 Jun;40(6):730-40
18669658 - Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10859-64
21427165 - Carcinogenesis. 2011 Jun;32(6):848-52
12740571 - Nat Med. 2003 Jun;9(6):744-9
15455378 - Int J Cancer. 2005 Jan 20;113(3):456-63
19629071 - Nat Rev Cancer. 2009 Aug;9(8):563-75
21131975 - Nat Genet. 2011 Jan;43(1):60-5
20131315 - Int J Cancer. 2010 Nov 1;127(9):2183-9
References_xml – volume: 105
  start-page: 10859
  year: 2008
  end-page: 10864
  ident: CR13
  article-title: Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0800647105
– volume: 81
  start-page: 559
  year: 2007
  end-page: 575
  ident: CR21
  article-title: PLINK: a tool set for whole-genome association and population-based linkage analyses
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 89
  start-page: 1277
  year: 1997
  end-page: 1284
  ident: CR2
  article-title: Tobacco, alcohol, and socioeconomic status and adenocarcinomas of the esophagus and gastric cardia
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/89.17.1277
– volume: 38
  start-page: 904
  year: 2006
  end-page: 909
  ident: CR20
  article-title: Principal components analysis corrects for stratification in genome-wide association studies
  publication-title: Nat. Genet.
  doi: 10.1038/ng1847
– volume: 9
  start-page: 563
  year: 2009
  end-page: 575
  ident: CR8
  article-title: The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2676
– volume: 3
  start-page: e58
  year: 2007
  ident: CR12
  article-title: Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.0030058
– volume: 113
  start-page: 456
  year: 2005
  end-page: 463
  ident: CR1
  article-title: Prospective study of risk factors for esophageal and gastric cancers in the Linxian general population trial cohort in China
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.20616
– volume: 40
  start-page: 730
  year: 2008
  end-page: 740
  ident: CR15
  article-title: Genetic variation in is associated with susceptibility to diffuse-type gastric cancer
  publication-title: Nat. Genet.
  doi: 10.1038/ng.152
– volume: 32
  start-page: 848
  year: 2011
  end-page: 852
  ident: CR18
  article-title: Genetic variants at 1q22 and 10q23 reproducibly associated with gastric cancer susceptibility in a Chinese population
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgr051
– volume: 140
  start-page: 92
  year: 2002
  end-page: 102
  ident: CR11
  article-title: Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines
  publication-title: J. Lab. Clin. Med.
  doi: 10.1016/S0022-2143(02)00023-9
– volume: 2
  start-page: 28
  year: 2002
  end-page: 37
  ident: CR4
  article-title: and gastrointestinal tract adenocarcinomas
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc703
– volume: 42
  start-page: 764
  year: 2010
  end-page: 767
  ident: CR6
  article-title: A shared susceptibility locus in at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.649
– volume: 282
  start-page: 1067
  year: 2001
  end-page: 1073
  ident: CR14
  article-title: Identification and characterization of DPZF, a novel human BTB/POZ zinc finger protein sharing homology to BCL-6
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.2001.4689
– volume: 21
  start-page: 1539
  year: 2002
  end-page: 1558
  ident: CR22
  article-title: Quantifying heterogeneity in a meta-analysis
  publication-title: Stat. Med.
  doi: 10.1002/sim.1186
– volume: 43
  start-page: 60
  year: 2011
  end-page: 65
  ident: CR19
  article-title: Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
  publication-title: Nat. Genet.
  doi: 10.1038/ng.723
– volume: 42
  start-page: 759
  year: 2010
  end-page: 763
  ident: CR5
  article-title: Genome-wide association study of esophageal squamous cell carcinoma in Chinese subjects identifies susceptibility loci at and
  publication-title: Nat. Genet.
  doi: 10.1038/ng.648
– volume: 48
  start-page: 1131
  year: 2009
  end-page: 1138
  ident: CR16
  article-title: Two genetic variants in prostate stem cell antigen and gastric cancer susceptibility in a Chinese population
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20565
– volume: 127
  start-page: 2183
  year: 2010
  end-page: 2189
  ident: CR17
  article-title: Genetic variation of gene is associated with the risk of both diffuse- and intestinal-type gastric cancer in a Chinese population
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.25228
– volume: 9
  start-page: 744
  year: 2003
  end-page: 749
  ident: CR10
  article-title: Prostaglandin E –EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
  publication-title: Nat. Med.
  doi: 10.1038/nm872
– volume: 282
  start-page: 11613
  year: 2007
  end-page: 11617
  ident: CR9
  article-title: Prostaglandin E receptors
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R600038200
– volume: 36
  start-page: 388
  year: 2004
  end-page: 393
  ident: CR7
  article-title: Assessing the impact of population stratification on genetic association studies
  publication-title: Nat. Genet.
  doi: 10.1038/ng1333
– volume: 132
  start-page: 3467S
  year: 2002
  end-page: 3470S
  ident: CR3
  article-title: Diet, obesity and reflux in the etiology of adenocarcinomas of the esophagus and gastric cardia in humans
  publication-title: J. Nutr.
  doi: 10.1093/jn/132.11.3467S
– volume: 42
  start-page: 764
  year: 2010
  ident: BFng978_CR6
  publication-title: Nat. Genet.
  doi: 10.1038/ng.649
– volume: 3
  start-page: e58
  year: 2007
  ident: BFng978_CR12
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.0030058
– volume: 282
  start-page: 11613
  year: 2007
  ident: BFng978_CR9
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R600038200
– volume: 9
  start-page: 744
  year: 2003
  ident: BFng978_CR10
  publication-title: Nat. Med.
  doi: 10.1038/nm872
– volume: 43
  start-page: 60
  year: 2011
  ident: BFng978_CR19
  publication-title: Nat. Genet.
  doi: 10.1038/ng.723
– volume: 38
  start-page: 904
  year: 2006
  ident: BFng978_CR20
  publication-title: Nat. Genet.
  doi: 10.1038/ng1847
– volume: 89
  start-page: 1277
  year: 1997
  ident: BFng978_CR2
  publication-title: J. Natl. Cancer Inst.
  doi: 10.1093/jnci/89.17.1277
– volume: 2
  start-page: 28
  year: 2002
  ident: BFng978_CR4
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc703
– volume: 282
  start-page: 1067
  year: 2001
  ident: BFng978_CR14
  publication-title: Biochem. Biophys. Res. Commun.
  doi: 10.1006/bbrc.2001.4689
– volume: 40
  start-page: 730
  year: 2008
  ident: BFng978_CR15
  publication-title: Nat. Genet.
  doi: 10.1038/ng.152
– volume: 127
  start-page: 2183
  year: 2010
  ident: BFng978_CR17
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.25228
– volume: 105
  start-page: 10859
  year: 2008
  ident: BFng978_CR13
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.0800647105
– volume: 81
  start-page: 559
  year: 2007
  ident: BFng978_CR21
  publication-title: Am. J. Hum. Genet.
  doi: 10.1086/519795
– volume: 42
  start-page: 759
  year: 2010
  ident: BFng978_CR5
  publication-title: Nat. Genet.
  doi: 10.1038/ng.648
– volume: 36
  start-page: 388
  year: 2004
  ident: BFng978_CR7
  publication-title: Nat. Genet.
  doi: 10.1038/ng1333
– volume: 21
  start-page: 1539
  year: 2002
  ident: BFng978_CR22
  publication-title: Stat. Med.
  doi: 10.1002/sim.1186
– volume: 113
  start-page: 456
  year: 2005
  ident: BFng978_CR1
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.20616
– volume: 32
  start-page: 848
  year: 2011
  ident: BFng978_CR18
  publication-title: Carcinogenesis
  doi: 10.1093/carcin/bgr051
– volume: 140
  start-page: 92
  year: 2002
  ident: BFng978_CR11
  publication-title: J. Lab. Clin. Med.
  doi: 10.1016/S0022-2143(02)00023-9
– volume: 48
  start-page: 1131
  year: 2009
  ident: BFng978_CR16
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20565
– volume: 9
  start-page: 563
  year: 2009
  ident: BFng978_CR8
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2676
– volume: 132
  start-page: 3467S
  year: 2002
  ident: BFng978_CR3
  publication-title: J. Nutr.
  doi: 10.1093/jn/132.11.3467S
– reference: 11352661 - Biochem Biophys Res Commun. 2001 Apr 13;282(4):1067-73
– reference: 21131975 - Nat Genet. 2011 Jan;43(1):60-5
– reference: 9293918 - J Natl Cancer Inst. 1997 Sep 3;89(17):1277-84
– reference: 12111919 - Stat Med. 2002 Jun 15;21(11):1539-58
– reference: 20131315 - Int J Cancer. 2010 Nov 1;127(9):2183-9
– reference: 15455378 - Int J Cancer. 2005 Jan 20;113(3):456-63
– reference: 19554573 - Mol Carcinog. 2009 Dec;48(12):1131-8
– reference: 18669658 - Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10859-64
– reference: 21427165 - Carcinogenesis. 2011 Jun;32(6):848-52
– reference: 20729853 - Nat Genet. 2010 Sep;42(9):759-63
– reference: 18488030 - Nat Genet. 2008 Jun;40(6):730-40
– reference: 17329241 - J Biol Chem. 2007 Apr 20;282(16):11613-7
– reference: 19629071 - Nat Rev Cancer. 2009 Aug;9(8):563-75
– reference: 12228765 - J Lab Clin Med. 2002 Aug;140(2):92-102
– reference: 12740571 - Nat Med. 2003 Jun;9(6):744-9
– reference: 15052270 - Nat Genet. 2004 Apr;36(4):388-93
– reference: 11902583 - Nat Rev Cancer. 2002 Jan;2(1):28-37
– reference: 12421872 - J Nutr. 2002 Nov;132(11 Suppl):3467S-3470S
– reference: 16862161 - Nat Genet. 2006 Aug;38(8):904-9
– reference: 17701901 - Am J Hum Genet. 2007 Sep;81(3):559-75
– reference: 17447842 - PLoS Genet. 2007 Apr 20;3(4):e58
– reference: 20729852 - Nat Genet. 2010 Sep;42(9):764-7
SSID ssj0014408
Score 2.5046692
Snippet Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously...
Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants...
SourceID proquest
gale
pubmed
pascalfrancis
crossref
springer
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1215
SubjectTerms 631/208/205/2138
631/208/727/2000
631/67/2324
692/699/67/1504/1829
Adult
Aged
Agriculture
AMP-Activated Protein Kinases - genetics
Animal Genetics and Genomics
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer Research
Case-Control Studies
Chromosomes, Human, Pair 3 - genetics
Chromosomes, Human, Pair 5 - genetics
Confidence intervals
Development and progression
Disease susceptibility
Female
Fundamental and applied biological sciences. Psychology
Gastroenterology. Liver. Pancreas. Abdomen
Gene Function
Genetic aspects
Genetic Loci
Genetics of eukaryotes. Biological and molecular evolution
Genome-Wide Association Study
Genomes
Health care
Human Genetics
Humans
letter
Male
Medical sciences
Middle Aged
Nerve Tissue Proteins - genetics
Odds Ratio
Pathogenesis
Polymorphism, Single Nucleotide
Public health
R&D
Receptors, Prostaglandin E, EP4 Subtype - genetics
Research & development
Risk factors
Sample size
Single nucleotide polymorphisms
Stomach cancer
Stomach Neoplasms - genetics
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Studies
Transcription Factors - genetics
Tumors
Title A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
URI https://link.springer.com/article/10.1038/ng.978
https://www.ncbi.nlm.nih.gov/pubmed/22037551
https://www.proquest.com/docview/912510659
https://www.proquest.com/docview/1034822127
https://www.proquest.com/docview/906559006
Volume 43
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3db9QwDLdgExLSNMH46j6OgEA8dWubNm2fptu0aSAx0GDo3qo0aU8nQe-23oH232Mnud6qMV6qSnXTJHYdO3b8A3ineVCXSV76aG2Ufpzy0i9jEfqSo0LOai0DEzH9fC7OLuNPo2TkcnNal1a51IlGUeupoj3yg5xWYgoCHs6ufAKNouCqQ9B4COtUuYyEOh11_haFLe1JOEFuEkUpLbQQzw6a8b5BVru1FjmNvDGTLc5ObWEt_mV33omZmqXo9AlsOhuSDS3Tn8KDqtmCRxZV8mYLNuxWHLMnjJ7B7yGjSqy_Kv_PRFdMrhjCTHFZNtE2ZahqGRrZrF20JtfFpM3eMFztJgxNW9ZMG18ZgWJjSXAfiimSmWsm54xfhRw9cyYbzZIZ3ofP4fL05Pvxme_gFnyFXtkc1V5eozHDNa_SJBIKbUEZiVToKA8CzXMpsjJNSllKqhmY4MqXKZGpQIo6q9CR5C9gDXtSvQImkdWxqKMaG4rDOpeRRi5QsbooibAND94vJ75QrhY5QWL8LExMnGdFMy6QQR687uhmtvrGHYq3xLeCSlk0lCszlou2LT5--VEMKQpNSEzJfUTfLnpEHxxRPcW-KOnOJ-CIqERWj3K3R4k_pOo9HvRkqOs5jp3Kx-Ue7CyFqnAaoy06-fbgTfeUWqYkuKaaLloadoz2XBilHrB7aHJsgoBghQcvrbiuPh8R3nES4stL-V19vj-r2__t4Q48NjvrJqlnF9bm14tqD02zeTkwPyBes-NwAOtHJ-dfL_4CYi82Pw
linkProvider ProQuest
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NIQTShGB8LGxsBjHxlC2xEzd5QKgaTC37QIJt2ltwnKSqNNJuaZn6R_E_cmcnLdEYb3urlKtj5853Z9_HD-BdJrwiDePURW8jdYOOSN00kL6rBCrkqMiUZyKmR8eydxp8OQ_Pl-B3UwtDaZWNTjSKOhtpuiPfjckSUxDw4_jSJdAoCq42CBpWKg7y2TWe2KoP_U_I3m3O9z-f7PXcGlTA1Xj2mODmjgs02SITeSfkUqPHo7jsyIzHnpeJWMko7YSpShV1xgtRv0daRtpTsohyPC4JHPce3A8E7kwqTN-bZ5RQmNRW3kk6llFU1EIZiWi3HOwYJLe_bF9tAVbGqkJuFBZG419-7o0YrTF9-0_gce2zsq4VsqewlJer8MCiWM5WYcVe_TFb0fQMfnUZdX79mbvXwyxnaiEAzDSzZcPMpijlFUOnnlXTyuTWmDTdGUPrOmToSrNyVLraCDAbKIIX0UyTjF4xNWHi0hc7wmeqzFg4xt_-czi9E068gGWcSb4GTKFoBbLgBQ4U-EWseIZcoOZ4POQ4hgPbzYdPdN37nCA4LhITgxdRUg4SZJADW3O6se32cYPiLfEtodYZJeXmDNS0qpL-17OkS1FvQn4KbyP6_q1F9L4mKkY4F63qeghcEbXkalFutChRAejW482WDM1njmundnWxA-uNUCW1hqqS-X5y4M38KY1MSXdlPppWtOwA_Uefdxxgt9DEOAQBz0oHXlpxXbyeE75y6OOfG_ldvL79VV_9d4Zb8LB3cnSYHPaPD9bhkbnVNwlFG7A8uZrmr9EtnKSbZjMy-HHXu_8PalhuGQ
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwED-NIdCkCcH4WNjYDGLiKWtjJ07ygFC1Ua0MBgKG9hYcJ6kqQdotLVP_NP477uykJRrjbW-VcnXs3Kd95_sBvMxEt0iDOHUx2khdPxSpm_rSc5VAgxwVmeqajOmHE3l06r87C85W4HdzF4bKKhubaAx1NtZ0Rt6JyRNTErBT1FURnw77bybnLgFIUaK1QdOwEnKczy9x91a9Hhwiq_c477_9enDk1gADrsZ9yBQVPS7QfYtM5GHApcboR3EZyozH3W4mYiWjNAxSlSrqkhegrY-0jHRXySLKceskcNxbcDsUYUQqFh0sqksoZWpv4UnaolGG1MIaiahTDvcNqttffrD2BusTVSFnCgup8a-Y90q-1rjB_n24V8evrGcF7gGs5OUG3LGIlvMNWLfHgMzebnoIv3qMusD-zN3LUZYztRQGZhrbslFmy5XyimGAz6pZZepsTMnunKGnHTEMq1k5Ll1thJkNFUGNaKZJXi-YmjJx7ol94TFVZiyY4G_vEZzeCCcewyrOJN8EplDMfFnwAgfyvSJWPEMuUKM8HnAcw4G95sMnuu6DTnAcPxKTjxdRUg4TZJADuwu6ie38cYXiBfEtoTYaJUnkUM2qKhl8_Jb0KANOKFDBdURfPreIXtVExRjnolV9NwJXRO25WpTbLUo0Brr1eKclQ4uZ49qpdV3swFYjVEltrapkoVsOPF88pZGpAK_Mx7OKlu1jLOnx0AF2DU2MQxAIrXTgiRXX5es5YS0HHv65kd_l69tf9el_Z7gLd1Hvk_eDk-MtWDMH_Ka2aBtWpxez_BlGiNN0x-gig-83rfx_AOrkck8
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+genome-wide+association+study+identifies+new+susceptibility+loci+for+non-cardia+gastric+cancer+at+3q13.31+and+5p13.1&rft.jtitle=Nature+genetics&rft.au=Shi%2C+Yongyong&rft.au=Hu%2C+Zhibin&rft.au=Wu%2C+Chen&rft.au=Dai%2C+Juncheng&rft.date=2011-12-01&rft.pub=Nature+Publishing+Group+US&rft.issn=1061-4036&rft.eissn=1546-1718&rft.volume=43&rft.issue=12&rft.spage=1215&rft.epage=1218&rft_id=info:doi/10.1038%2Fng.978&rft.externalDocID=10_1038_ng_978
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1061-4036&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1061-4036&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1061-4036&client=summon