A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1

• Published in: Nature genetics Vol. 43; no. 12; pp. 1215 - 1218
• Main Authors: Shi, Yongyong, Hu, Zhibin, Wu, Chen, Dai, Juncheng, Li, Huizhang, Dong, Jing, Wang, Meilin, Miao, Xiaoping, Zhou, Yifeng, Lu, Feng, Zhang, Hanze, Hu, Lingmin, Jiang, Yue, Li, Zhiqiang, Chu, Minjie, Ma, Hongxia, Chen, Jiaping, Jin, Guangfu, Tan, Wen, Wu, Tangchun, Zhang, Zhengdong, Lin, Dongxin, Shen, Hongbing
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.12.2011; Nature Publishing Group
• Subjects: 631/208/205/2138; 631/208/727/2000; 631/67/2324; 692/699/67/1504/1829; Adult; Aged; Agriculture; AMP-Activated Protein Kinases - genetics; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Case-Control Studies; Chromosomes, Human, Pair 3 - genetics; Chromosomes, Human, Pair 5 - genetics; Confidence intervals; Development and progression; Disease susceptibility; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Function; Genetic aspects; Genetic Loci; Genetics of eukaryotes. Biological and molecular evolution; Genome-Wide Association Study; Genomes; Health care; Human Genetics; Humans; letter; Male; Medical sciences; Middle Aged; Nerve Tissue Proteins - genetics; Odds Ratio; Pathogenesis; Polymorphism, Single Nucleotide; Public health; R&D; Receptors, Prostaglandin E, EP4 Subtype - genetics; Research & development; Risk factors; Sample size; Single nucleotide polymorphisms; Stomach cancer; Stomach Neoplasms - genetics; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Studies; Transcription Factors - genetics; Tumors; China; Digestive diseases; Identification; Malignant tumor; Locus; Stomach cancer; Cancer; Gastric disease
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.978

Hongbing Shen, Dongxin Lin, Yongyong Shi and colleagues identify two new susceptibility loci for non-cardia gastric cancer. They also confirm three previously reported risk loci for this gastric cancer subtype. Gastric cancer, including the cardia and non-cardia types, is the second leading cause of cancer-related deaths worldwide. To identify genetic risk variants for non-cardia gastric cancer, we performed a genome-wide association study in 3,279 individuals (1,006 with non-cardia gastric cancer and 2,273 controls) of Chinese descent. We replicated significant associations in an additional 6,897 subjects (3,288 with non-cardia gastric cancer and 3,609 controls). We identified two new susceptibility loci for non-cardia gastric cancer at 5p13.1 (rs13361707 in the region including PTGER4 and PRKAA1 ; odds ratio (OR) = 1.41; P = 7.6 × 10 −29 ) and 3q13.31 (rs9841504 in ZBTB20 ; OR = 0.76; P = 1.7 × 10 −9 ). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population.