Oct-3 and the Beginning of Mammalian Development

• Published in: Science (American Association for the Advancement of Science) Vol. 253; no. 5016; pp. 144 - 145
• Main Authors: Rosner, Mitchell H., Vigano, M. Alessandra, Peter W. J. Rigby, Arnheiter, Heinz, Staudt, Louis M.
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for the Advancement of Science 12.07.1991; American Association for the Advancement of Science; The American Association for the Advancement of Science
• Subjects: Animals; Biological and medical sciences; Cancer; Cell lines; Cellular biology; Developmental genetics; DNA; DNA Replication; DNA-Binding Proteins - physiology; Embryo, Mammalian - physiology; Embryology: invertebrates and vertebrates. Teratology; Embryos; Fundamental and applied biological sciences. Psychology; Gene Expression Regulation; Genes; Genetic aspects; Genetic regulation; Genetic transcription; Genetics; Germ cells; Mammals; Medical research; Messenger RNA; Mice; Molecular embryology; Octamer Transcription Factor-3; Perspective; Pluripotent stem cells; Regulation; Stem cells; Stem Cells - physiology; Teratoma - genetics; Teratoma - pathology; Totipotent stem cells; Transcription (Genetics); Transcription factors; Transcription Factors - physiology; Embryonic development; Embryo; Gastrulation; Stem cell; Regulator gene; Review; Germinal cell; Gene expression; Regulation(control); Vertebrata; Mammalia; Pluripotent cell; Early
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.1853199

In an effort to isolate regulatory genes active at earlier stages in mammalian development, recent investigations have focused on transcription factors that are expressed in undifferentiated, but not differentiated, embryonal carcinoma and embryonic stem cell lines. The first regulatory gene, Oct-3, to be identified this way is explored.