Heat shock protein 90 is downregulated in calcific aortic valve disease

• Published in: BMC cardiovascular disorders Vol. 19; no. 1; p. 306
• Main Authors: Weisell, Jonna, Ohukainen, Pauli, Näpänkangas, Juha, Ohlmeier, Steffen, Bergmann, Ulrich, Peltonen, Tuomas, Taskinen, Panu, Ruskoaho, Heikki, Rysä, Jaana
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 19.12.2019; BioMed Central; BMC
• Subjects: Annexins; Anopheles; Aortic valve insufficiency; Aortic valve stenosis; Calcification (Physiology); Calcified aortic valve disease; Comparative analysis; EDTA; Electrophoresis; Health maintenance organizations; Heart valve diseases; Heat shock proteins; Heat-shock protein; Immunohistochemistry; Mass spectrometry; Novels; Proteomics; Spectroscopy; Stenosis; Surgery; Calcified aortic valve disease; Aortic valve stenosis; Heat-shock protein; Proteomics

Calcific aortic valve disease (CAVD) is an atheroinflammatory process; finally it leads to progressive calcification of the valve. There is no effective pharmacological treatment for CAVD and many of the underlying molecular mechanisms remain unknown. We conducted a proteomic study to reveal novel f...