IgG4-related Autoimmune Prostatitis: Two Cases with or without Autoimmune Pancreatitis

Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without an...

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Bibliographic Details
Published inInternal Medicine Vol. 46; no. 24; pp. 1983 - 1990
Main Authors Nishimori, Isao, Kohsaki, Takuhiro, Onishi, Saburo, Shuin, Taro, Kohsaki, Shino, Ogawa, Yasuhiro, Matsumoto, Manabu, Hiroi, Makoto, Hamano, Hideaki, Kawa, Shigeyuki
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 01.01.2007
Subjects
Aged
Autoimmune Diseases - complications
Autoimmune Diseases - diagnosis
Autoimmune Diseases - immunology
autoimmune pancreatitis
Disease Progression
Humans
IgG4-related sclerosing disease
Immunoglobulin G - blood
Immunoglobulin G - immunology
Male
Middle Aged
Pancreatitis - complications
Pancreatitis - diagnosis
Pancreatitis - immunology
positron emission tomography with [18F] fluorodeoxyglucose
Positron-Emission Tomography
Prostate - immunology
Prostate - pathology
prostatitis
Prostatitis - diagnosis
Prostatitis - etiology
Prostatitis - immunology
steroid therapy
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Summary:Recently, autoimmune pancreatitis (AIP) has been reported with a variety of extra-pancreatic manifestations and infiltration of IgG4-positive cells into the affected organs. We report herein two cases with prostatitis. One was seen in a patient with typical AIP, and the other was observed without any clinical manifestation of AIP. Serum IgG4 levels were elevated in both cases. Histological examination of the prostates showed that parenchymal cells were partially or totally replaced with fibrosis and abundant infiltration of IgG4-positive cells. Significant uptake of [18F] fluorodeoxyglucose by the prostate was seen in both cases. In the case with AIP, the uptake completely disappeared after steroid therapy. The findings observed in these cases suggest that the pathological mechanism for prostatitis is similar to the mechanism previously implicated in AIP, namely IgG4-related autoimmune prostatitis.
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ISSN:0918-2918
1349-7235
1349-7235
DOI:10.2169/internalmedicine.46.0452