Role of an Exclusion Diet (Reduced Disaccharides, Saturated Fats, Emulsifiers, Red and Ultraprocessed Meats) in Maintaining the Remission of Chronic Inflammatory Bowel Diseases in Adults

• Published in: Medicina (Kaunas, Lithuania) Vol. 59; no. 2; p. 329
• Main Authors: Nitescu, Maria, Istratescu, Doina, Preda, Carmen Monica, Manuc, Teodora Ecaterina, Louis, Edouard, Manuc, Mircea, Stroie, Tudor, Catrinoiu, Mihai, Tieranu, Cristian George, Badea, Larisa Emanuela, Tugui, Letitia, Andrei, Adriana, Diculescu, Mihai Mircea
• Format: Journal Article Web Resource
• Language: English
• Published: Switzerland MDPI AG 09.02.2023; Lietuvos Gydytoju Sajunga; MDPI
• Subjects: Animals; Anti-inflammatory diet; Blood tests; Colitis, Ulcerative - therapy; Compliance; Crohn Disease - therapy; Crohns disease; Crohn’s disease; Diet; Diet therapy; Disaccharides; exclusion diet; Fatty acids; Food additives; Fruits; Gastroenterology & hepatology; Gastroentérologie & hépatologie; Health aspects; Human health sciences; Hypotheses; Hypothesis testing; Immunology; Inflammation; Inflammatory bowel disease; Inflammatory bowel diseases; Inflammatory Bowel Diseases - therapy; Meat; Microbiota; Nutrition research; Patient outcomes; Patients; Questionnaires; Reducing diets; Regression (Disease); Remission (Medicine); Saturated fatty acids; Sciences de la santé humaine; Sugars; ulcerative colitis; Romania; Western Europe; exclusion diet; ulcerative colitis; inflammatory bowel disease; Crohn’s disease
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina59020329

: Inflammatory bowel diseases are a main focus in current research, with diet being an emerging therapeutic line due to its links in both onset and progression. A Western-style diet high in processed foods, food additives, red meat, and animal fat has been linked to a higher risk of developing IBD. The aim of this study was to establish an association between an anti-inflammatory exclusion diet and maintenance of remission in IBD. Also, we assessed the efficacy and safety of this diet compared to a non-dietary group and the possible therapeutic effect of this diet in the maintenance of IBD remission. : A total of 160 patients with IBD were screened for inclusion, but 21 did not met the inclusion criteria. Thus, 139 patients were assigned to either an exclusion diet or a regular diet according to their choice. : Clinical remission after six months was maintained in the exclusion diet arm (100%). In the control arm, four patients had clinically active disease (one patient with UC and three with CD), and 90 patients maintained the clinical remission state (95.7%) ( -value = 0.157). Regarding biochemical markers, ESR at baseline was higher in the exclusion diet arm: 29 (5-62) versus in the control arm 16 (4-48) ( -value = 0.019), but six months after, the groups were similar ( -value = 0.440). : Patients who followed an exclusion diet maintained clinical remission more frequently. However, the threshold for statistical significance was not achieved. There was also a trend of improvement in inflammation tests in the intervention group.