Early progress in epigenetic regulation of endothelin pathway genes

Control of gene transcription is a major regulatory determinant for function of the endothelin pathway. Epigenetic mechanisms act on tissue‐specific gene expression during development and in response to physiological stimuli. Most of the limited evidence available on epigenetic regulation of the end...

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Bibliographic Details
Published inBritish journal of pharmacology Vol. 168; no. 2; pp. 327 - 334
Main Authors Welch, AK, Jacobs, ME, Wingo, CS, Cain, BD
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.2013
Subjects
Animals
DNA Methylation
endothelin
endothelin receptor
Endothelins - genetics
Epigenesis, Genetic
Epigenetics
Gene expression
histone modifications
Histones - metabolism
Humans
Themed Section: Endothelin
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Summary:Control of gene transcription is a major regulatory determinant for function of the endothelin pathway. Epigenetic mechanisms act on tissue‐specific gene expression during development and in response to physiological stimuli. Most of the limited evidence available on epigenetic regulation of the endothelin pathway focuses on the EDN1 and EDNRB genes. Examination of whole genome databases suggests that both genes are influenced by histone modifications and DNA methylation. This interpretation is supported by studies directed at detecting epigenetic action on the two genes. The clearest illustration of epigenetic factors altering endothelin signalling is DNA methylation‐associated EDNRB silencing during tumourigenesis. This review summarizes our current understanding of epigenetic regulation of the endothelin pathway genes. LINKED ARTICLES This article is part of a themed section on Endothelin. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2013.168.issue-2
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ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.2012.01826.x