Decreased transcriptional corepressor p107 is associated with exercise‐induced mitochondrial biogenesis in human skeletal muscle

• Published in: Physiological reports Vol. 5; no. 5; pp. np - n/a
• Main Authors: Bhattacharya, Debasmita, Ydfors, Mia, Hughes, Meghan C., Norrbom, Jessica, Perry, Christopher G. R., Scimè, Anthony
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.03.2017; John Wiley and Sons Inc
• Subjects: Adult; Biopsy; Biosynthesis; Cell cycle; Dietary fiber; Electron transport chain; Endurance and Performance; Exercise; Exercise - physiology; Gene expression; Gene silencing; human; Humans; Male; Medicin och hälsovetenskap; Metabolism; Mitochondria; mitochondrial biogenesis; Muscle, Skeletal - metabolism; Musculoskeletal system; Organelle Biogenesis; Original Research; Oxidative Phosphorylation; OXPHOS; Phosphorylation; Physical Endurance - physiology; Physiology; Protein expression; Proteins; Rb family; Retinoblastoma protein; Retinoblastoma Protein - genetics; Retinoblastoma Protein - metabolism; Retinoblastoma-Like Protein p107 - genetics; Retinoblastoma-Like Protein p107 - metabolism; Signalling Pathways; Skeletal Muscle; Transcription factors; Young Adult; OXPHOS; Rb family; Exercise; human; mitochondrial biogenesis
• ISSN: 2051-817X; 2051-817X
• DOI: 10.14814/phy2.13155

Increased mitochondrial content is a hallmark of exercise‐induced skeletal muscle remodeling. For this process, considerable evidence underscores the involvement of transcriptional coactivators in mediating mitochondrial biogenesis. However, our knowledge regarding the role of transcriptional corepressors is lacking. In this study, we assessed the association of the transcriptional corepressor Rb family proteins, Rb and p107, with endurance exercise‐induced mitochondrial adaptation in human skeletal muscle. We showed that p107, but not Rb, protein levels decrease by 3 weeks of high‐intensity interval training. This is associated with significant inverse association between p107 and exercise‐induced improved mitochondrial oxidative phosphorylation. Indeed, p107 showed significant reciprocal correlations with the protein contents of representative markers of mitochondrial electron transport chain complexes. These findings in human skeletal muscle suggest that attenuated transcriptional repression through p107 may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise. We show that the transcriptional corepressor, p107, is inversely correlated with exercise‐induced improved mitochondrial biogenesis and OXPHOS. Thus, attenuated transcriptional repression may be a novel mechanism by which exercise stimulates mitochondrial biogenesis following exercise.