提高肝脏免疫功能认知,加强肝病细胞治疗研究

肝脏是一个重要的免疫器官,具有独特的免疫微环境,参与全身固有免疫应答和适应性免疫反应。肝脏通过肝-肠轴与系统免疫密切相连,又是免疫损伤的靶器官;肝脏在抗嗜肝病毒免疫中发挥着重要作用,但导致病毒感染慢性化机制尚不完全清楚。肝病细胞治疗包括以细胞功能替代为主的肝（干）细胞输入治疗;以抗病毒抗肿瘤为主的免疫细胞治疗和对遗传性肝病进行的以细胞为载体的基因治疗。间充质干细胞的多向分化潜能和免疫调节特性成为肝病细胞治疗的热点,体外高效扩增技术使自然杀伤细胞治疗肝癌成为可能。...

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Bibliographic Details
Published in临床肝胆病杂志 Vol. 30; no. 9; pp. 839 - 841
Main Author 贾战生 连建奇
Format Journal Article
LanguageChinese
Published 第四军医大学唐都医院 感染病·肝病中心，西安710038 2014
Subjects
免疫
细胞治疗
肝疾病
述评
editorial
免疫
肝疾病
述评
细胞治疗
cell therapy
immuity
liver diseases
Online AccessGet full text
ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.09.001

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Summary:肝脏是一个重要的免疫器官,具有独特的免疫微环境,参与全身固有免疫应答和适应性免疫反应。肝脏通过肝-肠轴与系统免疫密切相连,又是免疫损伤的靶器官;肝脏在抗嗜肝病毒免疫中发挥着重要作用,但导致病毒感染慢性化机制尚不完全清楚。肝病细胞治疗包括以细胞功能替代为主的肝（干）细胞输入治疗;以抗病毒抗肿瘤为主的免疫细胞治疗和对遗传性肝病进行的以细胞为载体的基因治疗。间充质干细胞的多向分化潜能和免疫调节特性成为肝病细胞治疗的热点,体外高效扩增技术使自然杀伤细胞治疗肝癌成为可能。
Bibliography:liver diseases; immuity; cell therapy; editorial
As an important immune organ,the liver has a unique immune microenvironment,and is one of the important places for innate immunity and adaptive immunity. The liver is closely connected with the immune system through the gut- liver axis and is also the target organ of immune injury. However,the defensive role of the liver for Hepadnaviridae remains unclear. Cell therapy for liver diseases includes input of liver cells or stem cells for functional replacement,therapy by immune cells for antiviral and antitumor purposes,and genetic therapy for hereditary hepatopathy with cells as the carrier. The features of mesenchymal stem cells,multi- directional differentiation potential and immunomodulatory property,become the hot spots of cell therapy for liver diseases,and efficient in vitro amplification of cells makes it possible for the use of NK cells in the treatment of hepatocellular carcinoma.
JIA Zhansheng, LIAN Jianqi. （ Center of lnfectious Diseases and Liver Diseas
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.09.001