Chronic Kidney Disease Stage Is a Modulator on the Association between High-Sensitivity C-Reactive Protein and Coronary Vasospastic Angina

• Published in: TheScientificWorld Vol. 2014; no. 2014; pp. 1 - 9
• Main Authors: Tsai, Chi-Jen, Wu, Mai-Szu, Hung, Ming-Jui, Chen, Chun-Yu, Chou, Chia-Chi, Sun, Chiao-Yin, Lee, Chin-Chan, Wu, I-Wen, Hsu, Kuang-Hung, Yen, Chiung-Hui, Hsu, Heng-Jung, Yang, Shih-Ying
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2014; John Wiley & Sons, Inc; Wiley
• Subjects: Aged; Angina pectoris; Angina Pectoris - metabolism; Autoimmune diseases; C-reactive protein; C-Reactive Protein - metabolism; Cardiology; Cardiovascular disease; Chronic kidney failure; Clinical Study; Coronary Artery Disease - metabolism; Coronary vasospasm; Coronary Vasospasm - metabolism; Coronary vessels; Diabetes; Female; Health aspects; Heart attacks; Humans; Hypertension; Intubation; Kidney diseases; Male; Middle Aged; Multivariate Analysis; Oxidative stress; Physiological aspects; Population; Proteins; Regression analysis; Renal Insufficiency, Chronic - metabolism; Smoking; Veins & arteries
• ISSN: 2356-6140; 1537-744X; 1537-744X
• DOI: 10.1155/2014/852507

The prevalence of coronary vasospasm and also the factors associated with coronary vasospasm in CKD is still unclear. In this cross-sectional study of 859 consecutive CKD patients with angina pectoris received coronary catheterization, we evaluated the factors associated with coronary vasospasm. Patients with vasospasm were older and had higher peripheral blood white cell counts, higher peripheral blood monocyte cell counts, higher haemoglobin levels, higher hs-CRP levels, and lower levels of serum creatinine than patients without vasospasm. The results of multivariate logistic regression analysis revealed that peripheral blood monocyte count and hs-CRP level were independently associated with coronary vasospasm in patients with stage 1 CKD. Only peripheral blood monocyte count but not hs-CRP was independently associated with coronary vasospasm in patients with stages 2 and 3 of CKD. In conclusion, peripheral blood monocyte count is independently associated with coronary vasospasm in patients with stage 1–3 CKD, whereas hs-CRP is only independently associated with coronary vasospasm in patients with stage 1 CKD.