Copper-catalyzed oxidative trimerization of indoles by using TEMPO to construct quaternary carbon centers: the synthesis of 2-(1H-indol-3-yl)-2,3′-biindolin-3-ones
A simple, convenient, and efficient synthesis of 2-(1H-indol-3-yl)-2,3′-biindolin-3-one derivatives has been developed by the oxidative trimeric reaction of indoles using the TEMPO/CuCl 2 catalyst system under ambient air. This methodology provides an alternative approach for the direct generation o...
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Published in | Canadian journal of chemistry Vol. 92; no. 4; pp. 269 - 273 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
OTTAWA
NRC Research Press
01.04.2014
CANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESS Canadian Science Publishing NRC Research Press |
Subjects | |
Online Access | Get full text |
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Summary: | A simple, convenient, and efficient synthesis of 2-(1H-indol-3-yl)-2,3′-biindolin-3-one derivatives has been developed by the oxidative trimeric reaction of indoles using the TEMPO/CuCl
2
catalyst system under ambient air. This methodology provides an alternative approach for the direct generation of all-carbon quaternary centers at the C-2 position of indoles. |
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ISSN: | 0008-4042 1480-3291 |
DOI: | 10.1139/cjc-2013-0435 |