Regulation of endothelial homeostasis, vascular development and angiogenesis by the transcription factor ERG

Abstract Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG al...

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Published inVascular pharmacology Vol. 86; pp. 3 - 13
Main Authors Shah, Aarti V, Birdsey, Graeme M, Randi, Anna M
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2016
Elsevier Science Ltd
Elsevier Science
Subjects
Angiogenesis
Animals
Cardiovascular
Ectopic expression
Endothelial homeostasis
Endothelium
Endothelium, Vascular - physiology
ETS protein
ETS transcription factors
Gene expression
Gene Expression Regulation
Gene transcription
Genes
Homeostasis
Humans
Inflammation
Neovascularization, Physiologic - genetics
Neovascularization, Physiologic - physiology
Prostate
Review
Transcription factors
Transcriptional Regulator ERG - genetics
Transcriptional Regulator ERG - metabolism
Tumorigenesis
Vascular development
Vascular endothelial growth factor
Angiogenesis
Endothelial homeostasis
ETS transcription factors
Vascular development
Gene transcription
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Summary:Abstract Over the last few years, the ETS transcription factor ERG has emerged as a major regulator of endothelial function. Multiple studies have shown that ERG plays a crucial role in promoting angiogenesis and vascular stability during development and after birth. In the mature vasculature ERG also functions to maintain endothelial homeostasis, by transactivating genes involved in key endothelial functions, whilst repressing expression of pro-inflammatory genes. Its homeostatic role is lineage-specific, since ectopic expression of ERG in non-endothelial tissues such as prostate is detrimental and contributes to oncogenesis. This review summarises the main roles and pathways controlled by ERG in the vascular endothelium, its transcriptional targets and its functional partners and the emerging evidence on the pathways regulating ERG's activity and expression.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
Current address: Division of Cardiovascular Medicine, Addenbrooke's Centre for Clinical Investigation, University of Cambridge, Cambridge, United Kingdom.
ISSN:1537-1891
1879-3649
DOI:10.1016/j.vph.2016.05.003