A changing profile of infective endocarditis at a tertiary hospital in China: a retrospective study from 2001 to 2018

• Published in: BMC infectious diseases Vol. 19; no. 1; p. 945
• Main Authors: Ren, Zuning, Mo, Xichao, Chen, Hongjie, Peng, Jie
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 08.11.2019; BioMed Central; BMC
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; China; Clinical characteristics; Echocardiography; Electronic records; Embolism; Endocarditis; Endocarditis, Bacterial - drug therapy; Endocarditis, Bacterial - microbiology; Endocarditis, Bacterial - mortality; Endocarditis, Bacterial - surgery; Female; Health aspects; Heart Failure; Heart valve diseases; Hospital Mortality; Hospital patients; Hospitals, University; Humans; Independent predictors; Infective endocarditis; Ischemia; Kidney failure; Male; Medical records; Medical research; Microbiology; Middle Aged; Mortality; Prostheses and implants; Pulmonary embolism; Renal Insufficiency; Retrospective Studies; Retrospective study; Risk Factors; Staphylococcal infections; Staphylococcal Infections - microbiology; Staphylococcus aureus infections; Streptococcal Infections - microbiology; Stroke; Tertiary Care Centers; Young Adult; China; Clinical characteristics; Infective endocarditis; Retrospective study; Independent predictors; Mortality; Risk factors
• ISSN: 1471-2334; 1471-2334
• DOI: 10.1186/s12879-019-4609-8

Infective endocarditis (IE) is a lethal disease which has been changing significantly over the past decades; however, information about IE in China remains scarce. This study surveyed the changes in clinical characteristics of IE at a tertiary hospital in south China over a period of nearly 18 years. Medical records with IE patients consecutively hospitalized between June 2001 and June 2018 were selected from the electronic medical records system in Nanfang Hospital of Southern Medical University. Data were divided by admission time into two groups equally: early-period group, June 2001 to December 2009 and later-period group, January 2010 to July 2018. A Total of 313 IE patients were included in our study. Compared with the early-period group, patients in the later-period group included fewer intravenous drug users (IVDUs), older age at onset, reduced development of pulmonary embolism, less renal dysfunction, decreased proportion of Staphylococcus aureus infection and fewer vegetations observed in the right heart by echocardiography. The later-period group also showed a higher proportion of ischemic strokes and higher proportion of positive microbiological findings compared with the early-period group. The in-hospital mortality remained about the same between the two periods and the multivariate analysis identified intravenous drug addicted, prosthetic valve endocarditis, hemorrhagic stroke, acute congestive heart failure, renal insufficiency, left-sided endocarditis, early surgical as independent predictors of in-hospital mortality. Our study demonstrated a dramatic change in the profile of IE over a period of 18 years at a tertiary hospital in south China and presented several independent predictors of in-hospital mortality. The geographic variations observed in our study will be of important value to profile the clinical feature of China and offer the reference for clinical decisions in our region.