Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas

• Published in: Haematologica (Roma) Vol. 94; no. 8; pp. 1109 - 1123
• Main Authors: Bende, Richard J, van Maldegem, Febe, van Noesel, Carel J.M
• Format: Journal Article
• Language: English
• Published: Pavia Ferrata Storti Foundation 01.08.2009
• Subjects: Animals; Autoimmune Diseases - genetics; Autoimmune Diseases - immunology; Autoimmune Diseases - metabolism; Biological and medical sciences; Cell Adhesion Molecules - metabolism; Chemokines - metabolism; Chronic Disease; Hematologic and hematopoietic diseases; Humans; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Lymphoid Tissue - immunology; Lymphoid Tissue - metabolism; Lymphoma, B-Cell - genetics; Lymphoma, B-Cell - immunology; Lymphoma, B-Cell - metabolism; Medical sciences; Models, Biological; Review; Translocation, Genetic; Immunoglobulins; Lymph node; Hematology; immunoglobulin; Chronic disease; Marginal zone lymphoma; Malignant hemopathy; Inflammation; B-Lymphocyte; extranodal marginal zone B-cell lymphoma; Lymphoid tissue; B lymphocyte receptor; Non Hodgkin lymphoma; Inflammatory disease; Chronic; lymphoid tissue neogenesis; Lymphoproliferative syndrome; B-cell non-Hodgkin's lymphoma; B-cell antigen receptor; Cancer
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.2009.005983

Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Correspondence: Carel J.M. van Noesel, Department of Pathology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. E-mail: c.j.vannoesel{at}amc.uva.nl Chronic autoimmune or pathogen-induced immune reactions resulting in lymphoid neogenesis are associated with development of malignant lymphomas, mostly extranodal marginal zone B-cell lymphomas (MZBCLs). In this review we address (i) chemokines and adhesion molecules involved in lymphoid neogenesis; (ii) the autoimmune diseases and pathogens which are associated with development of B-cell lymphomas; (iii) the molecular mechanisms involved in the initiation and progression of MZBCL; and (iv) ‘potential’ mouse models for MZBCL. Key words: B-cell non-Hodgkin’s lymphoma, extranodal marginal zone B-cell lymphoma, immunoglobulin, B-cell antigen receptor, inflammation, lymphoid tissue neogenesis.