Whole Eye Axial Biometry During Accommodation Using Ultra-long Scan Depth Optical Coherence Tomography

• Published in: American journal of ophthalmology Vol. 157; no. 5; pp. 1064 - 1069.e2
• Main Authors: Zhong, Jianguang, Tao, Aizhu, Xu, Zhe, Jiang, Hong, Shao, Yilei, Zhang, Huicheng, Liu, Che, Wang, Jianhua
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.05.2014; Elsevier Limited
• Subjects: Accommodation, Ocular - physiology; Adult; Anterior Chamber - anatomy & histology; Axial Length, Eye - anatomy & histology; Biometrics; Biometry; Cornea - anatomy & histology; Disclosure; Female; Humans; Lens, Crystalline - anatomy & histology; Male; Measurement techniques; Ophthalmology; Optics; Prospective Studies; Software; Studies; Tomography, Optical Coherence - methods; Vitreous Body - anatomy & histology; Young Adult; California
• ISSN: 0002-9394; 1879-1891
• DOI: 10.1016/j.ajo.2014.01.016

Purpose To investigate changes of whole eye axial biometry during accommodation using ultra-long scan depth optical coherence tomography (UL-OCT). Design Prospective, observational case series. Methods Twenty-one adult subjects were enrolled. Using UL-OCT, the left eye of each subject was imaged with relaxed diopters (0 D) and accommodative stimuli (+6 D). Full eye biometry included central corneal thickness (CCT), anterior chamber depth (ACD), lens thickness, vitreous length, and axial length (AL). Results During accommodation (+6 D), the axial biometry of the whole eye changed significantly. Compared to the rest state, ACD at the accommodative state decreased significantly from 3.128 ± 0.305 mm to 2.961 ± 0.298 mm (paired t test, P < .001). The lens thickness increased significantly from 3.723 ± 0.237 mm to 3.963 ± 0.234 mm ( P < .001). The vitreous length decreased significantly from 17.129 ± 0.864 mm to 17.057 ± 0.848 mm ( P < .001). AL was 24.519 ± 0.917 mm at the rest state and increased to 24.545 ± 0.915 mm with +6 D accommodation stimulus. The elongated AL of 26.1 ± 13.4 μm between the rest and accommodative states was significant ( P < .001). Conclusions During accommodation, whole eye axial biometry changed, including a decrease in ACD and vitreous length and an increase in lens thickness and AL. UL-OCT provides an alternative method that is suitable for full eye biometry during accommodation.