Effect of Nephrotomy on Renal Function and Morphology in Normal Cats
To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. Controlled, randomized, blinded experiment. Ten adult female cats. Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using ⁹⁹mTechnetium-diethylenetriamine-pentaacet...
Saved in:
Published in | Veterinary surgery Vol. 35; no. 8; pp. 749 - 758 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Malden, USA
Malden, USA : Blackwell Publishing Inc
01.12.2006
Blackwell Publishing Inc Blackwell Publishing Ltd |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | To assess effects over 12 weeks of bisection nephrotomy on renal function, size, and morphology in cats. Controlled, randomized, blinded experiment. Ten adult female cats. Glomerular filtration rate (GFR), determined by quantitative renal scintigraphy using ⁹⁹mTechnetium-diethylenetriamine-pentaacetic acid, urinalysis, urine culture, and ultrasonographic measurement of renal size were performed preoperatively. Left or right nephrotomy (5 cats/group) was performed. Total and individual kidney GFRs were determined at 2, 28, and 84 days, ultrasonographic measurements at 28 and 86 days, and ultrasound-guided biopsy at 86 days. No significant differences in mean GFR and kidney size of operated versus unoperated kidneys were observed. Individual GFR and renal size of all except 1 cat remained within normal limits. Two cats had evidence of transient ureteral obstruction in the immediate postoperative period. No significant, generalized histologic abnormalities were observed. Bisection nephrotomy in normal cats does not adversely affect renal function or morphology during the initial 12 weeks. Bisection nephrotomy can be safely performed in normal feline kidneys without causing a significant deleterious effect on renal function. Studies in cats with pre-existing renal insufficiency are needed to ensure adverse effects would not occur in clinical cases where this surgical procedure is warranted. |
---|---|
Bibliography: | http://dx.doi.org/10.1111/j.1532-950X.2006.00219.x ArticleID:VSU00219 ark:/67375/WNG-SPNX518Z-C istex:C0827141F8A6D616592F162A6BEAE2C9662AAA2F Dr. Zimmerman‐Pope's current address is Dallas Veterinary Surgical Center, Dallas, TX. Funded by a grant from the Virginia Veterinary Medical Association. Presented at the ACVS Veterinary Symposium, San Diego, CA, October 2005. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0161-3499 1532-950X |
DOI: | 10.1111/j.1532-950X.2006.00219.x |