High Bone Resorption in Adult Aging Transgenic Mice Overexpressing Cbfa1/Runx2 in Cells of the Osteoblastic Lineage

• Published in: Molecular and Cellular Biology Vol. 22; no. 17; pp. 6222 - 6233
• Main Authors: Geoffroy, Valérie, Kneissel, Michaela, Fournier, Brigitte, Boyde, Alan, Matthias, Patrick
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.09.2002; Taylor & Francis
• Subjects: Aging - metabolism; Animals; Bone Density; Bone Diseases, Metabolic - genetics; Bone Diseases, Metabolic - metabolism; Bone Diseases, Metabolic - pathology; Bone Marrow Cells - pathology; Bone Matrix - metabolism; Bone Resorption - genetics; Bone Resorption - metabolism; Bone Resorption - pathology; Carrier Proteins - biosynthesis; Carrier Proteins - genetics; Cell Differentiation - physiology; Cell Growth and Development; Cell Lineage; Cells, Cultured - metabolism; Cells, Cultured - pathology; Coculture Techniques; Collagen - genetics; Collagenases - biosynthesis; Collagenases - genetics; Core Binding Factor Alpha 1 Subunit; Core Binding Factors; Female; Genotype; Glycoproteins - biosynthesis; Glycoproteins - genetics; Male; Matrix Metalloproteinase 13; Membrane Glycoproteins - biosynthesis; Membrane Glycoproteins - genetics; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins; Osteoblasts - metabolism; Osteoclasts - pathology; Osteoprotegerin; Promoter Regions, Genetic; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptors, Cytoplasmic and Nuclear - biosynthesis; Receptors, Cytoplasmic and Nuclear - genetics; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins - biosynthesis; Recombinant Fusion Proteins - physiology; Spleen - pathology; Stromal Cells - pathology; Transcription Factors - genetics; Transcription Factors - physiology
• ISSN: 0270-7306; 1098-5549; 1098-5549
• DOI: 10.1128/MCB.22.17.6222-6233.2002

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