Inactivated and adjuvanted whole-virion clade 2.3.4 H5N1 pre-pandemic influenza vaccine possesses broad protective efficacy against infection by heterologous clades of highly pathogenic H5N1 avian influenza virus in mice

• Published in: Vaccine Vol. 29; no. 46; pp. 8330 - 8337
• Main Authors: Harada, Yuichi, Ninomiya-Mori, Ai, Takahashi, Yoshimasa, Shirakura, Masayuki, Kishida, Noriko, Kageyama, Tsutomu, Tada, Yoshikazu, Tashiro, Masato, Odagiri, Takato
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 26.10.2011; Elsevier; Elsevier Limited
• Subjects: Adjuvanted H5N1 whole virion pre-pandemic influenza vaccine; Adjuvants; Adjuvants, Immunologic - administration & dosage; Allergy and Immunology; aluminum; Aluminum hydroxide; Aluminum Hydroxide - administration & dosage; Animals; antibodies; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Antigenic variants; antigens; Applied microbiology; Avian influenza virus; Biological and medical sciences; blood serum; Body Weight; Combined vaccines; Cross Protection; Cross Reactions; Cross-neutralizing antibodies; Cross-protective immunity; Data processing; Epidemiology; Female; Fowl plague; Fundamental and applied biological sciences. Psychology; H5N1 avian influenza; immune response; Immunity; Immunogenicity; Immunoglobulin G; Immunoglobulin G - blood; Infection; influenza; Influenza A virus; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - immunology; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Mice; Mice, Inbred BALB C; Microbiology; Miscellaneous; Mortality; neutralization tests; Orthomyxoviridae Infections - mortality; Orthomyxoviridae Infections - pathology; Orthomyxoviridae Infections - prevention & control; Pandemics; Poultry; Proteins; Studies; Survival; Survival Analysis; survival rate; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Viral infections; Virology; virulence; Viruses; weight loss; Hong Kong China; Japan; China; Cross-protective immunity; Cross-neutralizing antibodies; H5N1 avian influenza; Adjuvanted H5N1 whole virion pre-pandemic influenza vaccine; Immunoprotection; Rodentia; Orthomyxoviridae; Zoopathogen; Vaccine; Adjuvanted H5N1 whole virion; Neutralizing antibody; Infection; Virus; Avian influenza; Vertebrata; Influenzavirus A; Mammalia; Avian influenzavirus; Mouse; Influenza A virus; pre-pandemic influenza vaccine; Efficiency; Viral disease; Immunological adjuvant; Cross immunity
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.08.091

Highlights ► Alum-adjuvanted H5N1 rgAnhui (clade 2.3.4) vaccine induced broad cross-reactive neutralizing antibodies. ► The rgAnhui vaccine elicited protective immunity in mice against challenge infections with heterologous clade H5N1 viruses. ► Vaccine formulation with alum adjuvant allowed sparing vaccine antigen.