Association between circulating SerpinB1 levels and insulin sensitivity in Japanese with type 2 diabetes: A single-center, cross-sectional, observational study

• Published in: PloS one Vol. 17; no. 11; p. e0276915
• Main Authors: Kyohara, Mayu, Miyashita, Daisuke, Inoue, Ryota, Nishiyama, Kuniyuki, Tsuno, Takahiro, Okuyama, Tomoko, Togashi, Yu, Terauchi, Yasuo, Shirakawa, Jun
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 04.11.2022; Public Library of Science (PLoS)
• Subjects: Age; Analysis; Beta cells; Biology and Life Sciences; Blood; Blood circulation; Blood glucose; Body mass index; Care and treatment; Cell proliferation; Cholesterol; Clinical trials; Creatinine; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diagnosis; Glucose; Glucose tolerance; Glucose tolerance tests; Health aspects; Homeostasis; Insulin; Insulin resistance; Liver; Low density lipoprotein; Medicine and Health Sciences; Metabolism; Normal distribution; Observational studies; Peptides; Physical Sciences; Prevention; Regression analysis; Research and Analysis Methods; Sensitivity; Triglycerides; Type 2 diabetes; Japan; United States > US
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0276915

Plasma and liver SerpinB1 levels are elevated in mice with insulin resistance and promote β-cell proliferation in human islets. We measured serum SerpinB1 levels in Japanese subjects with or without type 2 diabetes (T2DM). We enrolled 12 normal glucose tolerance (NGT) and 51 T2DM subjects. There was no difference in serum SerpinB1 levels between the 2 groups (T2DM, 1.3 ± 0.9 ng/mL vs . NGT, 1.8 ± 1.7 ng/mL; P = 0.146). After adjusting for age and sex, the serum SerpinB1 levels were positively correlated with HOMA2-%S (β = 0.319, P = 0.036), and negatively correlated with fasting blood glucose (β = -0.365, P = 0.010), total cholesterol (β = -0.396, P = 0.006), low-density lipoprotein (LDL) cholesterol (β = -0.411, P = 0.004), triglycerides (β = -0.321, P = 0.026), and γGTP (β = -0.322, P = 0.026) in subjects with T2DM. Thus, circulating SerpinB1 is possibly associated with insulin sensitivity and better blood glucose level in Japanese subjects with T2DM. Trial registration: UMIN Clinical Trials Registry, UMIN000020453 .