Quantitative analysis of neutralizing antibody response to human cytomegalovirus in natural infection

• Published in: Vaccine Vol. 29; no. 48; pp. 9075 - 9080
• Main Authors: Wang, Dai, Li, Fengsheng, Freed, Daniel C, Finnefrock, Adam C, Tang, Aimin, Grimes, Shannon N, Casimiro, Danilo R, Fu, Tong-Ming
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 08.11.2011; Elsevier; Elsevier Limited
• Subjects: adaptive immunity; Adult; Aged; Aged, 80 and over; Allergy and Immunology; Antibodies, Neutralizing - blood; Antibodies, Viral - blood; Applied microbiology; Artificial chromosomes; Biological and medical sciences; Biomarker; biomarkers; blood serum; Cell Line; children; Clinical trials; Cytomegalovirus; Cytomegalovirus - immunology; Cytomegalovirus Infections - immunology; Epithelial cells; Epithelial Cells - immunology; Epithelial Cells - virology; Female; fibroblasts; Fibroblasts - immunology; Fibroblasts - virology; Fundamental and applied biological sciences. Psychology; Human cytomegalovirus; Human herpesvirus 5; Humans; immune response; Infections; Microbiology; Middle Aged; Miscellaneous; Natural infection; neutralization; Neutralization Tests; neutralizing antibodies; Neutralizing antibody; Proteins; quantitative analysis; risk; Studies; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Virology; viruses; women; Young Adult; United States > US; Cytomegalovirus; Biomarker; Vaccines; Epithelial cells; Neutralizing antibody; Natural infection; Immune response; Herpesviridae; Biological marker; Vaccine; Betaherpesvirinae; Human cytomegalovirus; Infection; Virus; Viral disease; Epithelial cell; Humoral immunity; Quantitative analysis
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2011.09.056

Highlights ► Natural cytomegalovirus infection in healthy women induces potent neutralizing antibodies against infection of both fibroblasts and epithelial cells. ► The serum neutralizing activities against cytomegalovirus infection are maintained at high levels throughout the child bearing age. ► The epithelial cell neutralizing titer induced by naturally acquired cytomegalovirus infection is potentially one of the biomarkers for vaccine efficacy.