Evaluation of absorption and depletion of florfenicol in European seabass Dicentrarchus labrax

• Published in: Veterinary medicine and science Vol. 7; no. 3; pp. 987 - 997
• Main Authors: Kogiannou, Dimitra, Nikoloudaki, Chrysanthi, Katharios, Pantelis, Triga, Adriana, Rigos, George
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.05.2021; John Wiley and Sons Inc; Wiley
• Subjects: Animals; Antibacterial agents; Aquaculture; Dicentrarchus labrax; Dosage; Drug dosages; Drug withdrawal; Epidemics; Farming; Feeds; Florfenicol; florfenicol amine; muscle plus skin; Original; Pathogens; Pharmacokinetics; Plasma; Skin; Tilapia; withdrawal time; United States > US; Germany; Mediterranean Area; pharmacokinetics; florfenicol; florfenicol amine; muscle plus skin; withdrawal time
• ISSN: 2053-1095; 2053-1095
• DOI: 10.1002/vms3.415

The pharmacokinetic properties and residue elimination of florfenicol (FLO) and its amine were investigated in European seabass Dicentrarchus labrax at 24°C. The trial mainly included analysis of FLO in plasma after a single dose dietary administration of 10 mg/kg and in muscle plus skin following a multiple dosing (10 mg kg−1 day−1 for 7 days) to estimate pharmacokinetics and residue depletion, respectively. The maximum plasma concentration of FLO was measured to be 1.64 μg/ml, 4 hr post administration. The elimination half‐life (t1/2b) and the area under the concentration‐time curve extrapolated to infinity (AUC0‐∞) were calculated to be 13.0 hr and 34.7 μg h−1 ml−1, respectively. Withdrawal times of FLO and its amine were calculated to be 46.3 degree‐days, indicating a fast removal from the edible tissues of treated European seabass. Overall, FLO can be considered as a potentially efficient antibacterial agent for farmed European seabass provided that additional efforts will be devoted towards its in vitro and clinical efficacy. First pharmacokinetic study of florfenicol in European seabass providing insights to enhance treatment schedule of a promising “off label” antibacterial compound. Information is also provided regarding consumer's safety.