Peroxisome-mitochondria interplay and disease

• Published in: Journal of inherited metabolic disease Vol. 38; no. 4; pp. 681 - 702
• Main Authors: Schrader, Michael, Costello, Joseph, Godinho, Luis F., Islinger, Markus
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.07.2015; Blackwell Publishing Ltd
• Subjects: Animals; Biochemistry; Fatty Acids - metabolism; Human Genetics; Humans; Internal Medicine; Medicine; Medicine & Public Health; Metabolic Diseases; Mitochondria - metabolism; Mitochondrial Diseases - genetics; Mitochondrial Diseases - metabolism; Mitochondrial Membranes - metabolism; Oxidation-Reduction; Pediatrics; Peroxisomal Disorders - genetics; Peroxisomal Disorders - metabolism; Peroxisomes - metabolism; Ssiem 2014; Virus Diseases - metabolism; Peroxisomal Membrane; Peroxisomal Target Signal; Last Eukaryotic Common Ancestor; Mitochondrial Fission; Zellweger Syndrome
• ISSN: 0141-8955; 1573-2665
• DOI: 10.1007/s10545-015-9819-7

Peroxisomes and mitochondria are ubiquitous, highly dynamic organelles with an oxidative type of metabolism in eukaryotic cells. Over the years, substantial evidence has been provided that peroxisomes and mitochondria exhibit a close functional interplay which impacts on human health and development. The so-called “peroxisome-mitochondria connection” includes metabolic cooperation in the degradation of fatty acids, a redox-sensitive relationship, an overlap in key components of the membrane fission machineries and cooperation in anti-viral signalling and defence. Furthermore, combined peroxisome-mitochondria disorders with defects in organelle division have been revealed. In this review, we present the latest progress in the emerging field of peroxisomal and mitochondrial interplay in mammals with a particular emphasis on cooperative fatty acid β-oxidation, redox interplay, organelle dynamics, cooperation in anti-viral signalling and the resulting implications for disease.