HBV/HCV重叠感染的研究进展

HBV是一种嗜肝DNA病毒，HBV DNA和HBV特异P蛋白由核壳包裹成为核心颗粒，再由脂蛋白外膜包裹成完整的病毒颗粒。HCV是黄病毒科病毒，为单股正链RNA。HBV和HCV均由肠道外途径传播，2种病毒常可由相同途径发生感染。归纳了HBV/HCV重叠感染的发病机制、与隐匿性HBV感染和肝细胞癌以及器官移植、HBV疫苗之间的关系，同时介绍了重叠感染的治疗。指出存在于患者体内的HBV和HCV在病毒学方面相互干扰，在病变方面相互叠加。...

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Published in临床肝胆病杂志 Vol. 30; no. 6; pp. 569 - 572
Main Author 何丽 胡萍 申焕君 张野 黄长形
Format Journal Article
LanguageChinese
Published 第四军医大学唐都医院 传染科,西安,710038 2014
Subjects
丙型肝炎病毒
乙型综述
乙型肝炎病毒
重叠感染
乙型综述
superinfection
hepatitis B virus
review
hepatitis C virus
丙型肝炎病毒
重叠感染
乙型肝炎病毒
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.06.024

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Summary:HBV是一种嗜肝DNA病毒，HBV DNA和HBV特异P蛋白由核壳包裹成为核心颗粒，再由脂蛋白外膜包裹成完整的病毒颗粒。HCV是黄病毒科病毒，为单股正链RNA。HBV和HCV均由肠道外途径传播，2种病毒常可由相同途径发生感染。归纳了HBV/HCV重叠感染的发病机制、与隐匿性HBV感染和肝细胞癌以及器官移植、HBV疫苗之间的关系，同时介绍了重叠感染的治疗。指出存在于患者体内的HBV和HCV在病毒学方面相互干扰，在病变方面相互叠加。
Bibliography:Hepatitis B virus （HBV）is a hepatotropic DNA virus;HBV DNA and special P protein are covered by capsid proteins to form core particles,which are then covered by lipoprotein to form complete virus particles.Hepatitis C virus （HCV）,which belongs to the Flavi-viridae family,is a single-stranded,positive-sense RNA.HBV and HCV are transmitted by parenteral route and may cause co-infection through the same route of transmission.The pathogenesis of HBV/HCV co-infection and its relationship with occult HBV infection,hepato-cellular carcinoma,organ transplantation,and HBV vaccine are reviewed.Meanwhile,the treatment of co -infection is presented.It is shown that HBV and HCV interfere with each other in terms of virology and pathology.
HE Li , HU Ping, SHEN Huanjun, et al. （ Department of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi＇ an 710038, China）
hepatitis B virus;hepatitis C virus;superinfection;review
22-1108/R
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.06.024