Induction of apoptotic cell death via accumulation of autophagosomes in rat granulosa cells

This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase a...

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Published inFertility and sterility Vol. 95; no. 4; pp. 1482 - 1486
Main Authors Choi, JongYeob, Ph.D, Jo, MinWha, M.S, Lee, EunYoung, M.S, Choi, DooSeok, M.D., Ph.D
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 15.03.2011
Elsevier
Subjects
Animals
Apoptosis
Apoptosis - physiology
autophagy
Autophagy - physiology
bcl-2
Biological and medical sciences
caspases
Cell Death - physiology
Female
granulosa cell
granulosa cells
Granulosa Cells - metabolism
Granulosa Cells - pathology
Gynecology. Andrology. Obstetrics
Internal Medicine
Lysosomes - metabolism
Lysosomes - pathology
Medical sciences
Obstetrics and Gynecology
Proto-Oncogene Proteins c-bcl-2 - biosynthesis
Rats
Rats, Sprague-Dawley
autophagy
bcl-2
granulosa cell
caspases
Apoptosis
Rat
Induction
Gynecology
Rodentia
Obstetrics
Accumulation
Vertebrata
Granulosa cell
Mammalia
Cell death
Animal
Triggering
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Summary:This study evaluated the effect of autophagosome accumulation on apoptotic cell death in granulosa cells from developing follicles. Our results indicate that the accumulation of autophagosomes induces apoptotic cell death of granulosa cells through decreased bcl-2 expression and subsequent caspase activation.
Bibliography:http://dx.doi.org/10.1016/j.fertnstert.2010.06.006
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2010.06.006