Cholinergic modulation of event-related oscillations (ERO)

• Published in: Brain research Vol. 1559; pp. 11 - 25
• Main Authors: Sanchez-Alavez, Manuel, Robledo, Patricia, Wills, Derek N, Havstad, James, Ehlers, Cindy L
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 22.04.2014; Elsevier
• Subjects: Acetilcolina; Acetylcholine - metabolism; Acoustic Stimulation; Amygdala - physiology; Animals; Auditory Perception - physiology; Basal Nucleus of Meynert - physiology; Basal Nucleus of Meynert - physiopathology; Biological and medical sciences; Brain - physiology; Brain Waves - physiology; Central nervous system; Cervell; Cholinergic Neurons - physiology; Cholinergic system; Electrodes, Implanted; Electroencefalografia; Electroencephalogram; Electroencephalography; Electrophysiology; Event related oscillation; Event-related potential; Evoked Potentials, Auditory - physiology; Fisiologia; Frontal Lobe - physiology; Fundamental and applied biological sciences. Psychology; Ganglis basals; Hippocampus - physiology; Neural Pathways; Neurology; Oscil·lació neural; Phase difference lock index; Phase lock index; Rats; Resposta evocada auditiva; Septal Nuclei - physiology; Septal Nuclei - physiopathology; Vertebrates: nervous system and sense organs; ERP; ERO; Amygdala; Electroencephalogram; Frontal Cortex; nucleus basalis magnocellularis; Medial Septum; Event-related potentials; Choline acetyltransferase; PLI; Event-related potential; phase difference lock index; PDLI; ANOVA; Phase lock index; DHPC; ChAT; NBM; phase locking index; Dorsal Hippocampus; FCTX; AD; AMYG; Event-related oscillations; EEG; MS; Ach; Alzheimer׳s disease; Cholinergic system; ROI; Analysis of Variance; region of interest; Acetylcholine; Event related oscillation; Phase difference lock index; Rat; Rodentia; Central nervous system; Electrophysiology; Cognition; Electroencephalography; Encephalon; Vertebrata; Mammalia; Animal; Oscillation; Event evoked potential; Cholinergic transmission
• ISSN: 0006-8993; 1872-6240
• DOI: 10.1016/j.brainres.2014.02.043

Abstract The cholinergic system in the brain modulates patterns of activity involved in general arousal, attention processing, memory and consciousness. In the present study we determined the effects of selective cholinergic lesions of the medial septum area (MS) or nucleus basalis magnocellularis (NBM) on amplitude and phase characteristics of event related oscillations (EROs). A time–frequency based representation was used to determine ERO energy, phase synchronization across trials, recorded within a structure (phase lock index, PLI), and phase synchronization across trials, recorded between brain structures (phase difference lock index, PDLI), in the frontal cortex (Fctx), dorsal hippocampus (DHPC) and central amygdala (Amyg). Lesions in MS produced: (1) decreases in ERO energy in delta, theta, alpha, beta and gamma frequencies in Amyg, (2) reductions in gamma ERO energy and PLI in Fctx, (3) decreases in PDLI between the Fctx–Amyg in the theta, alpha, beta and gamma frequencies, and (4) decreases in PDLI between the DHPC–Amyg and Fctx–DHPC in the theta frequency bands. Lesions in NBM resulted in: (1) increased ERO energy in delta and theta frequency bands in Fctx, (2) reduced gamma ERO energy in Fctx and Amyg, (3) reductions in PLI in the theta, beta and gamma frequency ranges in Fctx, (4) reductions in gamma PLI in DHPC and (5) reduced beta PLI in Amyg. These studies suggest that the MS cholinergic system can alter phase synchronization between brain areas whereas the NBM cholinergic system modifies phase synchronization/phase resetting within a brain area.