Downregulation of the Ras–Mitogen-Activated Protein Kinase Pathway by the EphB2 Receptor Tyrosine Kinase Is Required for Ephrin-Induced Neurite Retraction

• Published in: Molecular and Cellular Biology Vol. 21; no. 21; pp. 7429 - 7441
• Main Authors: Elowe, Sabine, Holland, Sacha J., Kulkarni, Sarang, Pawson, Tony
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.11.2001; Taylor & Francis
• Subjects: Animals; Blotting, Western; Cell Division; Cell Growth and Development; Cell Line; COS Cells; Cytoplasm - metabolism; Cytoskeleton - metabolism; DNA, Complementary - metabolism; Down-Regulation; Enzyme Activation; EphB2 protein; Ephrin-B1; Fibronectins - metabolism; GTP; GTPase-activating protein; Humans; MAP Kinase Signaling System; Membrane Proteins - metabolism; Mitogen-Activated Protein Kinase 1 - metabolism; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases - metabolism; Neurites - metabolism; Neurons - metabolism; p120 protein; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; ras Proteins - metabolism; Rats; Receptor Protein-Tyrosine Kinases - chemistry; Receptor Protein-Tyrosine Kinases - metabolism; Receptor, EphB2; Receptor, EphB4; Receptors, Eph Family; Signal Transduction; Time Factors; Tumor Cells, Cultured

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